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*For medical professionals only
A higher level of circulating cell-free DNA in the blood may mean a higher
risk of chronic inflammation.
Higher levels of circulating cell-free DNA in the blood may mean a higher risk of chronic inflammation, which is associated
with early symptoms of weakness and dementia.
JOHUS Hopkins Medical Group, Oct.
11 --
In a long-term prospective study of more than 600 elderly participants, Johns Hopkins Medical Group (Johns Researchers at Hopkins Medicine say they have evidence that higher levels of circulating cell-free DNA (ccfDNA) in the blood may mean a higher risk of chronic inflammation, which is associated with early symptoms of weakness and dementia
。
The findings, published today in the Journal of Alzheimer's Disease, could spur research into relatively simple blood tests to detect the risk of Alzheimer's disease and other forms of cognitive decline
。 The study was published on October 11, 2022 in the Journal of Alzheimer's Disease (latest impact factor: 4.
160) Circulating cell-free genomic
DNA, ccf-gDNA) is the product
of natural cell death in the human body.
When cells die through apoptosis (programmed cell death), the cells shrink, the plasma membrane degrades, and eventually ruptures and releases its contents, including DNA fragments
, into the body.
These fragments eventually become free DNA
in the blood.
"These ccf-gDNA fragments may trigger long-term chronic inflammatory responses that have previously been associated with premature destruction and aging of tissues and organs, including the brain "Peter Abadir, MD, associate professor of geriatrics and gerontology at Johns Hopkins University School of Medicine (JHUSOM), says, "The body sees these ccf-gDNA fragments as something to be cleared, so the body's immune system is operating at a higher rate than it should.
"
。 This overload of the immune system may be a factor in identifying the onset of dementia.
In
the new study, the researchers tested the blood of 631 people with an average age of 79 who did not show cognitive impairment
at the start of the study.
Participants underwent annual physical and cognitive tests
at each blood draw.
Researchers found that higher levels of ccf-gDNA in the blood were associated
with cognitive decline and worsening weakness during the 8-year study period.
According to the Alzheimer's Association, Alzheimer's disease affects approximately 6.
5 million people in the United States, and there is currently no known cure or effective therapy
.
However, the potential for blood tests to identify high-risk groups or early patients may lead to supportive services and other interventions to plan, compensate, or slow worsening symptoms
.
"Our world's population is ageing
rapidly.
Lolita Nidadavolu, MD, assistant professor of geriatrics and gerontology at JHUSOM, said
, "We've made so many advances that have helped us live longer, so the goal now is to live healthier lives as we age.
" The incidence of dementia and frailty is increasing
.
Many people know people
affected by these diseases.
With just one blood draw, we have the potential to determine who could benefit from
early intervention.
Going forward, the researchers say they hope to learn more about the cellular origins
of ccf-gDNA fragments.
If researchers can identify large numbers of these fragments from specific types of cells, they could hopefully advance research
into drugs that target the aging and dementia process.
Founded in 1893 Johns Hopkins University School of Medicine References: Lolita S.
Nidadavolu, Danielle Feger, Yuqiong Wu, Francine Grodstein, Alden L.
Gross, David A.
Bennett, Jeremy D.
Walston, Esther S.
Oh, Peter M.
Abadir.
Circulating Cell-Free Genomic DNA Is Associated with an Increased Risk of Dementia and with Change in Cognitive and Physical Function.
Journal of Alzheimer's Disease, 2022; 89 (4): 1233 DOI: 10.
3233/JAD-220301 Source: Alzheimer's disease Author: Alzheimer's
disease responsible editor: 66
Questionnaire survey
Stroke (commonly known as "stroke") has the characteristics of "four highs" with high morbidity, high disability rate, high mortality rate and high recurrence rate, acute onset, rapid progression and serious consequences, 1 in every 4 people in the world will have a stroke, 1 person will die of stroke every 6 seconds, and 1 person will be disabled due to stroke every 6 seconds, and the patient's family will suffer huge economic losses and physical and mental suffering
.
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, nor does it assume any responsibility
arising from the fact that the content is out of date and the cited information may be inaccurate or incomplete.
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