The length of lymphocytes telomerase is associated with the risk of meningioma

Telomerase is a basic nucleoprotein reverse transcriptase that is responsible for the repair and prolongation of telomeres in cellsSingle nucleotide polymorphism sites (SNPs) associated with telomere length were associated with the incidence and survival of malignant brain tumors such as gliomasIvo SMuskens of Neurosurgery at Brigham and Women's Hospital, Harvard Medical School, USA, and others have verified the effects of genetically determined lymphocyte telomere (LTL) on the development of meningioma by comparing non-malignant meningiomas associated with telomerase in healthy controls, and the results are published online february 2019 in Journal of Neuro-Oncologystudy methods
study included 1503 surgical lym patients and 4,437 healthy controls, and genotyped the DNA of 8 SNPs significantly associated with LTLEight SNPs are located in ACYP2 (rs1125529), TERC (rs10936599), NAF1 (rs7675998), TERT (rs2736100)), OBFC1 (rs9420907), CTC1 (rs3027234), ZNF08 (rs8105767) and RTEL1 (rs755017)The estimated LTL of the genotype was added to the value added of the telomere length specified by the SNPs genotype in the base pair (bp)Using two main genetic backgrounds and genders as covariates, logistic arithmetic regression was used to analyze the effects of genotype LTL on the occurrence of meningioma in the biotype-based control group and the healthy control groupresultsresults show that 3 of the eight LTL-related SNPs were significantly associated with an increased risk of meningioma, i.ers10936599 (OR?14; 95% CI, 1.01-1.28) ), rs2736100 (OR?1.13; 95% CI, 1.03-1.25) and rs9420907 (OR?1.22; 95% CI, 1.07-1.39)Adjusting for multiple promiscuous factors showed that rs9420907 was significantly associated with an increased risk of meningiomaCompared to the control group, the average LTL was estimated for SNPs genotype in meningioma patients, 560.2 bp, SE s 4.05 bp, and the control group was 541.5 bp, and SE s 2.02 bp (p 0.05)the study is the first to assess the relationship between lymphocytic telomere length and the incidence of meningiomaThe data are population-based and sample sizes are relatively largeThe advantage of using genetic genes to estimate LTL is that the results are determined at birth and are not affected by known external factors affecting telomere length, such as age and changes in smoking Therefore, usually the LTL of SNPs genotype estimation does not need to control the promixor or consider the relationship between reverse causality conclusions finally, the authors believe that LTL is significantly associated with an increased risk of meningioma The role of LTL in the pathogenesis of meningioma is still unknown, but the results may provide new evidence for the etiology of meningioma.