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Radiotherapy (radiotherapy) is one of the main treatment methods for malignant tumors, and radiotherapy resistance is the main reason for limiting the efficacy of tumor radiotherapy
Metabolic disorders are an important feature of malignant tumors
Recently, the team of Professor Guan Jian from the Department of Radiotherapy of Nanfang Hospital published a research paper titled "COMMD10 inhibits HIF1α/CP loop to enhance ferroptosis and radiosensitivity by disrupting Cu-Fe balance in hepatocellular carcinoma" in the Journal of Hepatology, a top international academic journal
This study revealed a new mechanism of tumor radioresistance mediated by copper metabolism disorders