[The Lancet] Prophet: Blood test in new brain injury patient predicts death, severe disability!

This article is original from Translational Medicine Network, please indicate the source for reprinting 

Author: Sophia

A blood test within 24 hours of a traumatic brain injury (TBI) can indicate which patients are likely to die and which may be severely disabled, according to a study led by the University of California, San Francisco, the University of Pennsylvania and the University of Michigan.

These tests, which detect two protein biomarkers, were approved by the U.

Background

 01 

These blood tests are "both diagnostic and prognostic," and are easy to administer, fast and inexpensive, said Geoffrey Manley, MD, of the University of California, San Francisco

One in five patients die or become severely disabled

 02 

About two-thirds of the patients, who had an average age of 39, were evaluated at 18 Level 1 trauma centers for injuries primarily caused by traffic accidents or falls

The researchers found that blood tests on the day of injury predicted a high probability of six-month death, 87% for GFAP and 89% for UCH-L1; and a high probability of predicting severe disability at the same time point, GFAP and UCH- The L1 prediction rates are both 86%

"We believe this tool may encourage clinicians to be more proactive when making decisions about starting or continuing life-saving treatments," Manley said.

The study is "the first report on the accuracy of a blood test that can be rapidly obtained on the day of injury to predict neurological recovery six months after injury," said Dr.

Prognostic model increases accuracy of blood tests

 03 

The researchers wanted to see if results would change if the two blood tests were performed together and combined with the accuracy of predicting outcomes and predictive models that looked at variables such as age, motor scores, pupillary reactivity and CT features

Structural brain injury detected by CT and MRI has been reported as an independent predictor of moderate and mild disability risk for mild TBI

TBI is a heterogeneous disease that requires "a rich and diverse dataset like the TRACK-TBI study," said Dr.

References:

https://medicalxpress.

This article is intended to introduce the progress of medical research and cannot be used as a reference for treatment plans

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