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Aging is associated with substantial inter-individual effects on function, morbidity, and mortality
An article reported in The Lancet Healthy Longevity conveys research findings that people with poor cardiovascular health at age 36 are predicted to have a higher brain age later in life, and men also tend to have older brain ages than men.
46 Research
Many studies examining variability in the biology of aging are limited by participant chronological age variability, reliance on retrospective data collection, and heterogeneity in image acquisition and processing
In the study, researchers applied a well-established brain age model to derive brain PAD from structural imaging of Insight 46 participants
Research result
In addition to its association with structural brain volume, brain PAD has been shown to predict 8-year mortality in individuals aged 70 and is associated with physical function, risk of developing dementia, and including Alzheimer's disease, multiple sclerosis mental illness, including depression and depression
Of the 502 participants enrolled in Insight 46, 456 (91%) were enrolled based on complete imaging, serum NFL and APOE data
The researchers also found that higher brain age was associated with higher blood levels of neurofilament light protein (NfL)
Significance
Dr Sara Imarisio, head of research at Alzheimer's Research UK, said: "The Insight 46 research is helping to uncover more about the complex relationships between the different factors that influence people's brain health throughout their lives
Professor Jonathan Schott (UCL Dementia Research Centre, UCL Queen Square Institute of Neurology) said: "We found that although the real ages of the people in this study were all very similar, the computer models predicted very different ages of their brains
References:
https://medicalxpress.
This article is intended to introduce the progress of medical research and cannot be used as a reference for treatment plans