The Instruction of (4-CHLORO-2-METHYLSULFANYL-PYRIMIDIN-5-YL)-METHANOL

The chemical compound (4-chloro-2-methylsulfanyl-pyrimidin-5-yl)-methanol, commonly referred to as 5-chloro-2-methylsulfanyl-pyrimidine (CAS number: 16670-64-6), is an important intermediate in the production of several pharmaceuticals, agrochemicals, and other chemical products.
Its unique chemical structure and properties make it a versatile building block for the synthesis of various organic compounds.
In this article, we will discuss the synthesis, applications, and safety precautions related to 5-chloro-2-methylsulfanyl-pyrimidine in the chemical industry.

Synthesis of 5-chloro-2-methylsulfanyl-pyrimidine
5-chloro-2-methylsulfanyl-pyrimidine can be synthesized by several methods, including direct sulfenylation of 2-methylthiophene-5-carbaldehyde, chlorination of 2,2-dimethyl-5-ethylthiopseudopyrimidine, and oxidation of 2-chloromethyl-5-methylthiopyrimidine.
The most commonly used methods involve the use of various reagents, solvents, and catalysts to achieve the desired product.

Applications of 5-chloro-2-methylsulfanyl-pyrimidine
5-chloro-2-methylsulfanyl-pyrimidine is widely used in the production of various pharmaceuticals, agrochemicals, and other chemical products.
It can be used as an intermediate in the synthesis of antibiotics, anti-inflammatory drugs, and anti-cancer agents.
It is also used in the production of herbicides, insecticides, and other agricultural chemicals.

One of the most notable applications of 5-chloro-2-methylsulfanyl-pyrimidine is in the synthesis of the anti-malarial drug, artesunate.
Artesunate is widely used in the treatment of malaria and is known for its efficacy and safety.
The synthesis of artesunate involves the conversion of 5-chloro-2-methylsulfanyl-pyrimidine into a series of intermediate compounds, which are eventually converted into artesunate.

Another application of 5-chloro-2-methylsulfanyl-pyrimidine is in the synthesis of herbicides, such as isocycloprid, which is used to control weeds in crops.
Isocycloprid is a potent herbicide with a low toxicity to mammals, making it an ideal choice for use in agriculture.

Safety precautions when handling 5-chloro-2-methylsulfanyl-pyrimidine
5-chloro-2-methylsulfanyl-pyrimidine is classified as a moderately toxic compound and can cause skin irritation, respiratory problems, and other health issues if proper safety precautions are not observed during handling.
It is important to wear protective clothing, including gloves, eye protection, and a face mask, when handling 5-chloro-2-methylsulfanyl-pyrimidine.
It is also important to avoid contact with the skin, ingestion, and inhalation of the compound.

In addition, the use of 5-chloro-2-methylsulfanyl-pyrimidine should be carried out in a well-ventilated area and away from any ignition sources, as it is highly