The Instruction of 2-Fluoro-4-methylphenylboronic acid

The Instruction of 2-Fluoro-4-methylphenylboronic acid: A Comprehensive Guide for the Chemical Industry

In the world of chemistry, there are countless compounds and reagents that are used to create new substances, materials, and products.
One of these compounds is 2-fluoro-4-methylphenylboronic acid, a highly versatile and useful boronic acid that has found application in a wide range of chemical processes and reactions.

What is 2-Fluoro-4-methylphenylboronic acid?

2-Fluoro-4-methylphenylboronic acid, also known as 2-FMPA or ZINC6646311, is a boronic acid derivative that contains a fluorine atom and a methyl group attached to a benzene ring.
The boron atom is bonded to the carbon atom of the benzene ring, making it a boronic acid.

The compound is classified as a racemate, meaning it contains two enantiomers that are mirror images of each other.
The two enantiomers are referred to as R-(+)-2-FMPA and S-(−)-2-FMPA.

Chemical structure of 2-Fluoro-4-methylphenylboronic acid

The chemical structure of 2-Fluoro-4-methylphenylboronic acid can be represented by the following structural formula:

        H
        |
       C-B
        |
        B(OH)2
         |
         F
        |
        C=C-C(=O)N(CH3)
        |
        C(=O)R'

In this structure, the boron atom is bonded to a carbon atom of a benzene ring, and is bonded to two hydroxyl groups.
The fluorine atom is bonded to a carbon atom of the same benzene ring.
The methyl group is bonded to another carbon atom of the same benzene ring, and is bonded to an amido group.
Finally, the amido group is bonded to a secondary amine, R'.

Physical and Chemical Properties of 2-Fluoro-4-methylphenylboronic acid

2-Fluoro-4-methylphenylboronic acid has a number of physical and chemical properties that make it useful for various applications in the chemical industry.
Some of these properties are:

• Melting Point: The melting point of 2-Fluoro-4-methylphenylboronic acid is 144-146°C.
  
• Boiling Point: The boiling point of 2-Fluoro-4-methylphenylboronic acid is 530-531°C.
  
• Solubility: 2-Fluoro-4-methylphenylboronic acid is slightly soluble in water, with a solubility of approximately 5 g/L at 25°C.
  
• pKa: The pKa of 2-Fluoro-4-methylphenylboronic acid is 9.
  7.
  
• Spectral Data: 2-Fluoro-4-methylphenylboronic acid has a number of absorption peaks in the IR spectrum, including peaks at 3100, 1650, and 1480 cm^-1.
  It also has a number of peaks in the NMR spectrum, including peaks at 8.
  01 and 7.
  68 ppm in the 1H NMR spectrum, and peaks at 6.
  98 and 6.
  86 ppm in the 13C NMR spectrum.
  

Applications of 2-Fluoro-4-methylphenylboronic acid

2-Fluoro-4-methylphenylboronic acid has a wide range of applications in the chemical industry due to its versatile chemical properties.
Some of the most common applications of 2-Fluoro-4-methylphenylboronic acid include:

• As a building block for the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals.
  
• As a reagent in organic synthesis, in