The Institute of Microbiology and others build an artificial intelligence-based virtual mutation assessment and early warning system for the new coronavirus

As the global COVID-19 control continues, the new coronavirusThe genome continues to mutate during the epidemic

At present, a variety of mutant strains with enhanced infectivity , including Alpha , Beta and Delta , have been found in many countries and regions around the world , especially the amino acid mutations accumulated at key sites, which have greatly changed the immunological characteristics of the virus.

Therefore, the existing basic database that mainly collects and displays data has been unable to meet the needs of future epidemic prevention and control.

Recently, the Ma Juncai / Hu Songnian team from the Institute of Microbiology of the Chinese Academy of Sciences , in cooperation with Peking University, the Computer Network Information Center of the Chinese Academy of Sciences and other teams , released the "New Coronavirus Variation Assessment and Early Warning System" ( SARS-CoV) in the international academic journal Nucleic Acids Research .

VarEPS is the world's first system for multi-dimensional risk assessment and early warning of known and virtual variants in the SARS-CoV-2 genome

On this basis, the system uses an artificial intelligence classifier algorithm to effectively group mutant strains in terms of transmission and affinity for neutralizing antibodies, and realizes risk assessment and early warning based on virus sequences

The system can not only be used as a tool for global virus mutation monitoring and tracking, but also based on virtual mutation and risk assessment models, providing effective reference information for precise prevention and control of new mutant strains and antibody vaccine design

The results of these studies was 10 Yue 11 on the date of Nucleic Acids Research , published online on the Institute of Microbiology of microbial resources and large data center Sunqing Lan, happy senior tied for the first author of the paper

　　The database is open and free to users around the world through the National Microbial Science Data Center NMDC , and can be freely accessed on .

　　Among them, " virus and mutation " displays in table form including lineage, single nucleotide polymorphism  (SNP)  number, and nucleotide and amino acid mutation information, and provides all relevant mutations and primer evaluation results for each virus sequence Separate page

　　Paper link: 

　　https://academic.

　　Figure 1.

Figure  2.