The incidence of colorectal cancer tends to be younger, and the starting age for screening has dropped to 45 years old

The USPSTF in the United States recommends reducing the starting age for colorectal cancer screening to 45 years old.

Colorectal cancer has always been a malignant disease with a very high fatality rate.

Recently, the US Preventive Services Task Force (USPSTF) released the latest colorectal cancer screening guidelines in JAMA.

According to the latest guidelines, colorectal cancer is most commonly diagnosed in the elderly 65-74 years old.
It has become the third leading cause of cancer death in the United States.
It is estimated that 52,980 people will die from colorectal cancer in 2021.
The guideline data shows that in the United States, 10.
5% of new colorectal cancer cases are concentrated in people under 50.
At the same time, from 2000-2002 to 2014-2016, the incidence of colorectal cancer among people aged 40-49 has increased.
Nearly 15%.
In 2016, 25.
6% of American adults of school age had never been screened for colorectal cancer, but in 2018, the proportion rose again, and 31.
2% of the population did not receive screening in time.

As the incidence of colorectal cancer is getting younger, the USPSTF combined with multiple investigations and studies, and pointed out in the guidelines that age is one of the most important risk factors for the onset of colorectal cancer, and the incidence rate increases with age.
At present, 94% of the The incidence of colorectal cancer is concentrated in adults over 45 years of age.
Therefore, groups with a family history of colorectal cancer, male groups, people with other diseases (such as obesity, diabetes), and people with disturbances in daily life (long-term smoking, alcoholism) are highly likely to develop colorectal cancer.
All should be screened regularly from the age of 45.
The guidelines also point out that even asymptomatic adults who do not belong to the above-mentioned groups should be screened for colorectal cancer from the age of 45.

In the latest guidelines, the USPSTF recommends two screening methods, fecal testing and visual testing, and gives the frequency of screening, among which:

▷ Stool testing includes high-sensitivity guaiac test (High-sensitivity gFOBT), immunochemical test (Faecal Immunochemical Test, FIT) and stool DNA immunochemical test (sDNA-FIT);

▷ Visual inspection includes colonoscopy, CT virtual colonography, flexible sigmoidoscopy, and sigmoidoscopy combined with FIT.

The USPSTF recommends that because various screening methods require different screening frequencies, screening locations, and preliminary preparations, at the same time, the methods of anesthesia or sedation during the examination and the procedures followed after abnormalities are found are different.
Clinicians and patients Various factors should be considered to choose the most appropriate screening method.

At present, the trend of rejuvenation of diseases seems to be more and more obvious.
This is a wake-up call for each of us.
In addition to maintaining a good and healthy life>(Biological Exploration)

Reference materials:

[1] [2]https://jamanetwork.
com/journals/jama/fullarticle/2779985?resultclick=1&appid=scweb&appid=scweb&alert=article