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Neutrophils are the largest number of white blood cells and are the body's first line of defense
against infection.
Caryl Boies, Professor Caryl Boies, and his team at Cold Spring Harbor Laboratory (CSHL), have identified a drug candidate that can prevent deadly lung inflammation
in mice by inhibiting a protein called PTP1B.
Tonks said: "When you think about COVID-19, acute lung injury and acute respiratory distress syndrome are the deadly aspects
of this disease.
Dongyan Song, a graduate student at Tonks, investigated whether the use of PTP1B inhibitor candidates could inhibit the fatal consequences
of neutrophil overactivity in mice.
The researchers took advantage of a natural process called neutrophil senescence, which the body uses to control the lifespan
of immune cells.
The project is part of
CSHL's COVID-19 related research project.
Tonks' lab studies signal transduction, a process that controls how cells respond
to signals from the environment.
PTP1B inhibitors protect against acute lung injury and regulate CXCR4 signaling in neutrophilsJCI Insight
