The immune response of asymptomatic infections with neo-corona pneumonia may be weak

the outbreak of new crown pneumonia, China's health care workers and researchers have done a lot of work, so that people's understanding of the virus gradually deepened. Recently, "Nature-Medicine" published a paper of Chinese researchers, the investigation found that infected with the new coronavirus SARS-CoV-2, but never produced any new coronary pneumonia (COVID-19) symptoms, the immune response to the virus may be weak. The study detailed clinical and immunological analysis of 37 asymptomatic infections with neo-corona pneumonia.Most new coronavirus infections develop mild to severe respiratory symptoms, including fever, cough and shortness of breath, 2-14 days after exposure to the virus. However, others who tested positive for the infection were asymptomatic or mild. But we don't know the clinical details of these patients.Huang Ailong of Chongqing Medical University and others studied 37 asymptomatic infections diagnosed in Wanzhou District of Chongqing before April 10, 2020, including 22 women and 15 men, aged between 8 and 75 (the medium age is 41). They found that the medium duration of virus discharge in these asymptomatic patients was 19 days, while in 37 patients with symptoms it was 14 days, and in the acute phase of infection (the virus can be detected in the respiratory tract), the level of virus-specific IgG antibodies in the former was much lower than that of the latter. Eight weeks after discharge, the level of mesoth antibodies decreased by 81.1% in asymptomatic patients and by 62.2% in patients with symptoms. In addition, the levels of 18 inflammatory cytokines and anti-inflammatory cytokines (cell signaling proteins) were lower in asymptomatic patients. The authors suggest that this suggests that asymptomatic patients may have a weaker immune response to new coronavirus infections.The authors also observed that the majority of asymptomatic patients began to have lower IgG levels within 2-3 months of infection, a result determined by chemical luminescent magnetase immunomegnet testing.They say the findings, along with previous analysis of meso-antibodies in people recovering from neocyclone pneumonia, highlight the potential risks of using an "immune passport" to support the continued use of public health interventions and extensive virus testing. In order to determine the duration of antibody-based immunity, further research is urgently needed in larger-scale asymptomatic and asymptomatic patients. (Bright Daily)