The image of the "super variant" Omicron spike protein of the swiping world is announced!

On November 27, the Multimodal Medical Laboratory of the Jesus Children's Hospital in Rome, Italy, released the world's first picture of the new coronavirus mutant strain Omicron

Comparison of spike protein mutations between Delta strain and Omi Keron strain.

The number of amino acid residues mutated in the delta mutant strain is 18, while in the new strain Omi Keron there are 43

"Super Mutant" Omicron

Omicron was first discovered in Botswana in southern Africa, and then quickly spread in Gauteng Province in South Africa

The WHO statement pointed out that the emergence of this variant coincides with the rapid increase in new crown cases in South Africa in recent days

After the Delta mutant strain, the recent epidemic trend in South Africa has been relatively flat, but since the emergence of Omicron, the curve of infected persons has once again shown an upward trend

According to the British Health and Safety Agency, Omicron's spike protein is completely different from the original new coronavirus strain on which the new coronavirus vaccine is based

The spike protein is "the key used by the virus to open the door to human cells", and variants of the new coronavirus with many mutations may bypass the body's immune system

However, the WHO said that little is known about this new variant strain.

3 cases of infection confirmed in Hong Kong

On November 27, Hong Kong confirmed 3 cases of infection, all of which were imported cases, including 1 male and 2 females, aged 47 to 72 years old, from the United Kingdom, India, and Russia.

Up to now, Belgium, the United Kingdom, Germany, Italy and the Czech Republic have all confirmed cases of Ome Keron; 85 people in the two flights from South Africa in the Netherlands tested positive for nucleic acid, and the Ministry of Health of the Netherlands said it was 95% sure 61 of them were confirmed to have been infected with Omicron; and Israel has announced the closure of the border after the discovery of 2 suspected cases of Omicron infection, banning all foreign travelers from entering the country, becoming the first country in the world to block the border due to the Omicron strain

How effective are new crown oral drugs and new crown vaccines on Omicron

According to reports from MedTrend Medical Trends, based on the design principles of Merck and Pfizer's new crown oral drugs, the two drugs have different targets and may have different therapeutic effects on patients infected with Omicron variants

For Merck, Molnupiravir's mechanism of action is to target the enzyme that the new coronavirus uses for self-reproduction, inserting wrong codes into its genetic code, thereby slowing its ability to spread and invade human cells

For Pfizer, Paxlovid belongs to the class of protease inhibitors, and its target is 3CLPro.

The difference between the two drugs is that Paxlovid directly inhibits the action of the new coronavirus RNA polymerase and blocks the virus replication process; while Molnupiravir does not block RNA replication, but instead gives the virus "fake" nucleoside analogues.

Compared with oral drugs for the new crown, vaccine products are more susceptible to the mutation of the viral spike protein.