The human body "sterilised" becomes the "helper" of cancer metastasis?

Read: Nature reveals how the body's "steriliser" became an "accomplice" to cancer metastasis, promising to stop the spread of cancer
neutrophils are immune cells that provide the body with its first line of defense against infectionHowever, this line of defense is sometimes less "solid" becauseneutrophils also have the ability to promote cell cell metastasis, and may sometimes "reverse"cancer cellsOn June 11,, Professor Song Erwei, a member of the Chinese Academy of Sciences and dean of Sun Yat-sen Memorial Hospital at Sun Yat-sen University, published a study online in nature, revealing the special mechanismby by which neutrophils help cancer cell metastasis spread2004, researchers first discovered that neutrophils can form a mesh structure (NET) outside their cellsThis is a DNA network that is encased in enzymes that are toxic to microorganisms and can capture and kill invading microorganismsHowever, there is growing evidence that NETs are also involved in tumor sourcing in the distant processa process that helps cancer cells spreadto uncover the mechanism by which neutrophils help spread tumor metastasis, the researchers first evaluated NET in primary and metastatic tumors in 544 breast cancer patients and found that large amounts of neutrophil immersion appeared in the liver before the tumor metastasized, the researchers also observed that a receptor called "CCDC25" exists on the surface ofcancer cells, which can bind to NET DNA with high specificity and affinity, making NET a chemometric factor for tumor cells, "attracting" cancer cells in the breast, colon, etcinto the liver to form new tumor"If, through imaging, a large group of neutrophils in the patient's liver is detected when breast cancer has not metastasized, it means that he has a high risk of liver metastasis," saidSongin further experiments, CCDC25 showed the ability to remove cancer cells from in vitro cultured human breast cancer cellsRemoving CCDC25 from the surface of mouse cancer cells compared to mice with Lipopolysaccharide molecule (LPS) induced inflammation treatment significantly reduced liver metastasis and lung metastasisat the end of the report, the researchers revealed how tumor cells benefit from this interaction with the networkthey used CCDC25 as a "bait" in biochemical techniques to screen out CCDC25-interactive proteins from cancer cells to identify a protein-integrator-linked kinase (ILK), which regulates processes such as cell migration and proliferationWhen ILK is removed or its downstream signal ingon seis pedagogis is disabled, the growth and in vitro movement of cancer cells are severely impaired, and in mice, transfer to the liver is reducedWriting in the same paper in Nature,'s Francis Crick Institute in the UK, Emma Nolan and Ilaria Malanchi, said the study represented a key development in curbing the spread of cancer or would help researchers develop a specific strategy to stop THE NET promoting cancer metastasisIn addition, the data provided in the paper also point to possible ways to predict liver metastasis by monitoring NET DNA in the bloodOf course, further research is needed to assess the feasibility of targeting CCDC25 for cancer treatmentReferences:'s Neutrophil 'safety net' causes cancer cells to metastasize and proliferatereveals a new mechanism for distant metastasis of tumors's DNA of neutrophil extra traps promotes cancer metastasis via CCDC25