The Guangdong Provincial Center for Disease Control and Prevention has successfully isolated a new strain of coronavirus in South Africa

Pharma.com January 7 According to the official website of the Guangdong Provincial Center for Disease Control and Prevention, on January 6, the Guangdong Provincial Center for Disease Control and Prevention successfully isolated 501Y.V2 South African mutant strain from a swallow swab imported from an overseas case of new crown pneumonia in South Africa.
This is the second time the CDC has detected and successfully isolated a new coronavirus strain since it discovered the B.1.1.7 mutation in a pharynx swab sample from a confirmed case of new corona pneumonia in the United Kingdom on January 2.
the case was a closed-circuit South African immigrant, male, 55, a South African national and an airline pilot.
entered Guangzhou from Singapore on the evening of December 8, 2020 and collected nasopharyngeal swabs for nucleic acid testing, which turned out to be positive.
the case was then transferred by negative pressure ambulance to the Eighth People's Hospital in Guangzhou for further isolation.
December 31, the Guangdong Provincial Center for Disease Control and Prevention received samples of case pharynx swabs collected by the Eighth People's Hospital of Guangzhou City, immediately carried out virus isolation and gene sequencing analysis, on the evening of January 5, 2021, through the re-review and identification of the original samples and virus isolation cultures, the virus genome sequence belongs to the B.1.351 subtype, the tip is 501Y.V2 South African mutant strain.
the case is still being treated at the Eighth People's Hospital in Guangzhou.
501Y. The genome sequence of the V2 South African mutant strain has 23 nucleotide variation points compared to the reference genome Wuh01 (serial number MN908947), which is different from the N501Y mutation with the British mutant B.1.1.7 subtype, except that it contains mutations at the two key points of S protein E484K and K417N, which have a potentially significant impact on the ability of the virus to infect.
501Y. The V2 South African mutant was first discovered in South Africa in mid-October 2020 and has been a major local strain since early November 2020.
, the mutant strain is now spreading rapidly in South Africa and has gradually replaced other types of new coronavirus transmitted in the country's Eastern Cape, Western Cape and KwaZulu-Natal provinces.
, according to the World Health Organization, as of January 5, 2021, the mutant had been found in seven countries except South Africa.
experts believe that the south African mutant's propagation and pathogenicity need to be further studied.
the Guangdong Provincial Center for Disease Control and Prevention has found the new coronavirus BRITISH mutant strain and the South African mutant strain, are imported from outside Guangdong Province since last September confirmed cases, asymptomatic infection samples for retrospective gene sequencing analysis found.
these cases can be captured by guangdong Province's sensitive disease surveillance system, timely integration into closed-loop management, resulting in a minimal risk of community infection.
The Guangdong Provincial Center for Disease Control and Prevention will continue to strengthen research on new coronavirus strains, closely track the evaluation of the immune protection effect of the new crown vaccine on mutant strains, strengthen the genetic sequencing and monitoring of mutant strains, and further implement prevention and control measures to ensure that the relevant mutants do not cause follow-up transmission in Guangdong Province.
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