The flux vaccination tool recreates the history of the virus

, published July 20 in Genomic Biology, showed that strains of the virus used in the U.S. Civil War vaccine had been identified and their genomes reconstructed.
the successful eradication of underflow through "vaccination" shows that this practice is crucial in human history. Ana Duggan, one of the co-authors of the paper and lead research team at McMaster University in Canada, conducted the study of the flux vaccine.
, according to New Scientist, is caused by the virus, which causes about 30 percent of deaths. In 1980, after a concerted global vaccination effort, the flux was officially eradicated.
early prevention of smallchim includes infecting people with the virus and developing a relatively mild disease that allows them to be vaccinated against small flower viruses. This is usually done by applying infected pus or sores to the skin's wounds, a process known as small-flower inoculation.
Duggan and colleagues collected genetic material from U.S. Civil War-era vaccination tools to identify the strains used to vaccinate against the flux. They analyzed five vaccination tools in the museum's collection, which were used by doctors in the Philadelphia area between the mid-19th and late 19th centuries.
kits contained surgical knives, tin boxes for sores, and small glass plates for mixing liquids collected from infected blisters. By analyzing sores and blisters in four kits, the team reconstructed the genomes of all viruses. In a kit with no direct evidence of biomass, the researchers soaked a tin box in a solution containing an enzyme that collects virus fragments without destroying the box.
all five viruses identified in the disease are strains of bovine pox virus, which is distantly related to smallpox and is the cause of bovine pox. No virus has a complete genetic material, which means it is not contagious. With the help of computer algorithms and reference to the complete sequence of the bovine pox virus gene, the team pieced together the virus fragments like a jigsaw puzzle.
strains from the 1940s to the 1970s, previously found in the 1940s and 1970s, are very similar, despite their global distribution. Duggan said, "It is almost certain that the decline in strain diversity in the 20th century was the result of widespread vaccination." Duggan
, said the study showed the efforts people had made to vaccinate for nearly 200 years before the flux was eradicated. (Source: China Science Daily Wenle)
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