The first successful implementation of car-t immunocytotherapy in Anhui Province

On August 11, Xiaolei, a 6-year-old child with leukemia, received car-t cell immunotherapy in the Department of Hematology, the Second Affiliated Hospital of Anhui Medical University After receiving car-t cell immunotherapy, his condition improved significantly and his face showed a happy smile Since the beginning of June, the Department of Hematology, the Second Affiliated Hospital of Anhui Medical University, has cooperated with the Weiming Institute of bioeconomy, Peking University of Anhui Province to successfully implement car-t cell immunotherapy for the first three leukemia patients, which is the first time in Anhui Province Car-t, or chimeric antigen receptor T cell immunotherapy Its basic principle is to use the patient's autoimmune cells to remove cancer cells, which belongs to cell therapy, rather than using drugs It first extracts T cells from patients' peripheral blood (blood outside the bone marrow), and then carries out gene engineering modification in the laboratory, large-scale amplification and then reinfusion into patients At this time, the recoded T cells can obtain the ability of specific recognition and attack and kill tumor cells, especially for leukemia cells, such as "cell missile", which can accurately "spot" leukemia cells without damaging normal cells Using the power of patients' autoimmune system to resist cancer is a subversive breakthrough in cancer research It is reported that the most mature and effective treatment is B-lymphocytic leukemia and lymphoma Car-t cells for other malignant tumors are under development, with a promising future The technicians used multi parameter flow cytometry to detect and analyze the leukemia cells in the bone marrow of patients before and after treatment The cell culture dish was placed in the incubator for about a week The technicians carried out the cell classification test of bone marrow smear under the microscope Technicians are checking the cell culture bag in the sterile laboratory Through the sterility test, phenotype analysis and function test, the preparation can be infused back to the small patients of the human body and the condition can be significantly relieved Both father and son have a bright and happy smile