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| Cover ten regions of different age groups |
| The first mouse brain metabolite map published |
Science and Technology Daily, Beijing, October 18 (Reporter Zhang Mengran) According to the latest issue of "Nature Communications", a research team from the University of California, Davis published the first mouse brain metabolite map
.
The data set covers 1,547 different molecules in 10 brain regions of male and female mice from puberty, adulthood, to old age
The senior author of the paper and Professor Oliver Fein from the Genome Center of the University of California, Davis said, “This is the world’s largest brain metabolome analysis
.
It covers 1,547 identified metabolites that can express energy and neurotransmitters in the brain.
Metabolomics is the "chemical fingerprint" that studies the metabolism of living cells
.
It uses advanced high-throughput technology to separate and identify all the different chemical substances or metabolites present in cells, tissues or organs at a given time
The researchers sampled mice at 3 weeks of age (adolescence), 16 weeks of age (early adulthood), 59 weeks of age (middle age), and 92 weeks of age (old age)
.
They observed ten separate brain regions with different functions
Research results show that the brain metabolome is significantly different between the brainstem and other brain areas that control vital functions such as breathing and blood pressure, and the brain that controls movement, speech, and thinking
.
In addition, specific sections showed high concentrations of metabolites related to specific receptors, such as adenosine, ceramide, and phospholipid ether
At the same time, the researchers did not find any significant metabolic differences between the brains of male and female mice
.
When the research team compared animals of different ages, they found that, overall, adult mice had the largest metabolic differences between brain slices
.
The differences between regions are smaller in adolescence and much smaller in very old age
In addition, lipid molecules especially show great differences in aging and trans-brain areas.
Fehn said that in very old age, the response system against oxidative stress becomes very active, and proteins begin to decompose at a faster rate.
Peptides
.
These changes are reflected in the metabolome
