The first in school history!

On February 16, the world's top academic journal Cell published a research paper online: "Virome characterization of game animals in Nanjing Agricultural University School of Veterinary Medicine/Frontier Intersection Research Institute, Sun Yat-sen University School of Medicine and Military Veterinary Research Institute and other domestic and foreign units.
China reveals a spectrum of emerging pathogens”
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The co-corresponding authors of the paper are Professor Su Shuo (Lead contact) from Nanjing Agricultural University, Professor Shi Mang from Sun Yat-Sen University, and Professor Edward Holmes from the University of Sydney
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He Wanting, a doctoral student of the school, Hou Xin, a doctoral student of Sun Yat-sen University, and Zhao Jin, a master student of the school are the co-first authors of the paper
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This is the first time that Nanjing Agricultural University has published research results in Cell as the first corresponding author unit, and it is also a breakthrough research progress in the field of animal infectious disease prevention and control in China
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According to statistics, more than 70% of the pathogens of human infectious diseases come from animals
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Therefore, studying the virus carrying situation and diversity of wild animals that may be in close contact with humans or livestock is crucial to the prevention and control of emerging infectious diseases in humans and livestock
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The paper conducted a systematic viral transcriptome study on samples from 1941 mammals of 18 species in 20 provinces in China, and found that 102 viruses in 13 viridae can infect mammals, of which 65 viruses were discovered for the first time.
In mammals, for example: Coypu rotavirus, Pangolin pestivirus, Bamboo rat sapovirus,
etc.

This study greatly expands the understanding of the diversity of viruses carried by a variety of wild animals, and provides an important scientific basis for the early warning and prevention of human and livestock diseases
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In this study, porcupine deltacoronavirus (Deltacoronavirus HKU17), bovine parainfluenza virus 3 (Bovine parainfluenza virus 3), Mammalian orthorubulavirus 5 (Mammalian orthorubulavirus 5), H9N2 subtype influenza virus (Influenza A virus H9N2) and other 21 viruses with potentially high transmission risk to humans and livestock
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It was found that raccoon dogs, civet cats, bamboo rats, porcupines, hedgehogs and other wild animals can carry coronaviruses.
Among them, the four new canine coronaviruses (CCoV) carried in the diarrhea raccoon dog samples and the latest reports that can cause human diseases The gene homology of the recombinant CCoV strain CCoV-HuPn-2018 reached 93.
65%-94.
27%; based on the analysis of the non-recombinant region in the virus spike protein (S), it was found that the four new raccoon dog CCoVs formed a single 's pedigree
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Therefore, the risk of cross-species transmission of this coronavirus deserves attention
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This study also found a variety of high abundance of rotavirus (Rotavirus), including A, B, C, D and I groups
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Animals such as rabbits, raccoon dogs, porcupines and nutria all carry rotavirus group
A.

At the same time, co-infection of rotavirus groups A, C and I with high abundance was found in raccoon dogs with diarrhea, suggesting that rotavirus has cross-species transmission and public health risks
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Although these wild animals are not necessarily reservoir hosts for these high-risk viruses, they may act as intermediate hosts through cross-species transmission, transmitting pathogens to humans and livestock
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The findings also show that some seemingly healthy animals can also carry viruses closely related to human disease and continue to spread between different species
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This once again highlights the risks of trade, consumption and close contact with game animals, and the importance of revealing wildlife as a potential driver of disease emergence
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At the same time, the research results can provide new ideas for the formulation of major epidemic prevention and control policies such as moving forward the prevention and control of emerging infectious diseases
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This research was supported by the National Natural Science Foundation of China (31922081) and other projects.
At the same time, the epidemiological study of raccoon dog coronavirus was supported by the national key research and development program project "The Epidemic Transmission Characteristics and Genetic Evolution of Livestock and Poultry Coronavirus (2021YFD1801101).
"Support funding
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