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The FDA approved Karyopharm's Xpovio (selinexor) for the treatment of multiple myeloma

 Last Update: 2020-12-24
 Source: Internet
 Author: User

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Multiple myeloma is a malignant tumor that invades the bone marrow due to abnormal growth of plasma cells.
multiple myeloma is mostly asymptomatic at first, if the disease worsens, there will be bone pain, often infected, anemia symptoms.
Karyopharm Therapeutics said recently that the FDA has approved Xpovio (selinexor) in combination with boronazome and dexamisson for the treatment of adult patients with multiple myeloma who have received at least one treatment.
approval is based on the latest data from the BOSTON III trial, which treated 402 patients with relapsed or incurable multiple myeloma with a 1-3 course of treatment.
participants were randomly divided into once-a-week Xpovio combined with weekly boron tezomethami combined with low-dose dexamisong.
progress-free lifetime (PFS) was evaluated at the main endpoint of the BOSTON III phase trial, and the overall mitigation rate (ORR), peripheral neuropathy rate, etc. were evaluated at the secondary endpoint.
results showed that the median PFS was 13.9 months in patients receiving Xpovio combined treatment, compared with 9.5 months in the control group.
orR (62.3%) in the Xpovio combined treatment group was significantly higher (76.4%) than the ORR (62.3%) that used boron-zomi jointly alone.
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