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Protein is the main force of our cells, but we don't even know what protein we carry
Cees Dekker explained: "In the past 30 years, nanopore-based DNA sequencing has evolved from an idea to an actual working device
Like a bead falling into the sewer
This new technology even reveals the characteristics of individual amino acids in peptides.
Cees Dekker added: “One of the cool features of our technology is that we can read a single peptide string again and again, and then we read the average of all the data from a single molecule, so that it can be basically 100% Identify this molecule with accuracy
This will give you a unique interpretation, which is a characteristic of a specific protein
Scan the barcode for identification
This new technology is very powerful in identifying individual proteins and mapping the subtle changes between them, just like a cashier in a supermarket scans a barcode to identify each product
A glimpse of the "dark matter" of biology
Using current nanopore peptide readers, researchers can start analyzing the proteins floating in our cells
Cees Dekker said, "We can continue to use this analogy: after the beads on the necklace are made, it still changes-some red beads have a phosphate group attached to them, some blue beads have a sugar group attached to it, etc.
Journal Reference :
Henry Brinkerhoff, Albert SW Kang, Jingqian Liu, Aleksei Aksimentiev, Cees Dekker.
