Southern snake vine extract has great potential for anti-tumor invasion and metastasis

Malignant tumor is one of the serious diseases endangering human life and health According to the statistics of the World Health Organization, the incidence of cancer in the world is 10 million every year, and the death rate is 7 million It is the second killer of human after cardiovascular disease Chemical synthesis of anticancer drugs is not only expensive, heavy economic burden for patients, but also toxic and side effects Therefore, in the comprehensive treatment of cancer, the role of natural drugs is increasingly important Celastrus, also known as the mountain wind, dragon subduing grass, rattan, etc., is a plant of Celastraceae It was originally recorded in the Qing Dynasty's "plant name map test", mainly distributed in the south of the Yangtze River in China Celastrus orbiculatus is a kind of plant medicine commonly used by the people It has the functions of expelling cold and dampness, detoxifying and detumescence It can treat the pain of muscles and bones, rheumatoid arthritis, lumbago and leg pain, amenorrhea, infantile convulsion, dysentery, and bruise It has a variety of biological activities The contents of terpenoids, flavonoids and alkaloids in the plant of Celastrus orbiculatus are relatively high The chemical components that can be separated from it include Begonia diterpenoid lactone a, (5 β, 8 α, 9 β, 10 α, 16 β) - 16 hydroxykaurane-18-oic acid, salicylic acid, 2,4, 6-trimethoxyphenol-1-o-β-d-glucoside, isoquercetin, quercetin-7-o-β-d-glucoside, (+) - catechin, vanillic acid, β - carotene, β - sitosterol, etc In July this year, a study published in the Journal of integrated traditional Chinese and Western medicine by scholars from Yangzhou University of China showed that the extract of Celastrus orbiculatus can down regulate the epithelial mesenchymal transformation in hypoxia induced human hepatocarcinoma cells In the experiment, different concentrations (160, 200 and 240 μ g / ml) of Celastrus orbiculatus extract were applied to hepatoma cells Cell activity, scratch test, MTT test and Transwell test were tested Cobalt chloride was used to establish cell hypoxia model, and the target proteins including mucoprotein and vimentin were detected The results showed that the extract of Celastrus orbiculatus could inhibit the proliferation and metastasis of hepatoma cells induced by hypoxia, and the effect was dose-dependent The markers of epithelial mesenchymal metastasis also showed dose-related inhibition The upstream signaling pathway proteins hypoxia inducible factor-1 α and Twist1 were also inhibited The extract of Celastrus orbiculatus had synergistic effect with YC-1, an inhibitor of hypoxia inducible factor In other words, the extract of Celastrus orbiculatus can inhibit the invasion and metastasis of tumor cells by inhibiting HIF-1 α / Twist1 signaling pathway In 2013, some people in China also applied for the patent of using Celastrus orbiculatus as an antidote After the roots or stems of Celastrus orbiculatus were dissolved in water with organic solvent, then extracted with petroleum ether, chloroform, benzene or cyclohexane, and then extracted with ethyl acetate or n-butanol, the extracted parts of ethyl acetate or n-butanol were concentrated and dried to have the antidote effect Extract of Celastrus orbiculatus It can be used to prepare antidotes or health products Compared with western medicine, traditional Chinese medicine plays an important role in some chronic diseases The efficient extraction of its effective components is the key to industrial production The pharmacological action and extraction method of Celastrus orbiculatus need to be developed The main reported pharmacological effects include anti-tumor, anti-inflammatory, immunomodulatory, antibacterial, antioxidant, anti fibrosis and anti fertility In order to better play the therapeutic effect, we should avoid other side effects while using one pharmacological effect.