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The European Union will review Merck's lung cancer-targeted drug Tepotinib

 Last Update: 2020-12-14
 Source: Internet
 Author: User

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European regulators will verify Merck's Tepotinib for certain types of lung cancer before testing the drug's market application.
Tepotinib is designed to treat advanced non-small cell lung cancer (NSCLC) in adults with the interstumin-epithortic conversion factor gene (MET) exon 14 (METex14) jump mutation.
the drug is a highly selective oral MET inhibitor, given once a day, showing hope for treatment in the critical Phase II VISION study.
study, the main endpoint was the objective mitigation rate of patients who were followed for at least nine months through an independent review.
in 99 patients who received follow-up for at least nine months, the objective remission rate of independent review was 46%, and the medium remission time of the joint biopsy group was 11.1 months.
as Merck points out, meTex14 jump mutations occur in about 3-4% of NSCLC cases and are associated with aggressive tumor behavior and poor clinical prognosmism.
, there is currently no treatment for such NSCLC patients in Europe, highlighting unseconded medical needs.
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