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Systemic lupus erythematosus (SLE) is an autoimmune disease that invades the connective tissues of the whole body.
Kidney involvement often occurs, called lupus nephritis (LN), which manifests as proteinuria, hematuria, and renal insufficiency.
LN usually occurs in Early in the course of SLE
.
1.
The pathogenesis of LN Although LN is regarded as a typical immune complex glomerulonephritis, the pathogenesis of LN involves a variety of mechanisms , including: gene expression leads to neutrophil activation, gene expression leads to myeloid and Increases in interferons and other pro-inflammatory mediators in other immune cell populations, release of neutrophil extracellular trap nets (NET), and complement activation
.
The glomerular damage pattern in glomerular diseases mediated by SLE and other immune complexes is mainly related to the formation position of immune deposits, which are mainly caused by anti-dsDNA
.
The pathogenesis of LN involves multiple mechanisms .
The most common abnormality in LN patients is proteinuria
LN is also the first symptom of some SLE patients
The currently widely used classification divides SLE-related glomerular diseases into 6 types based on the results of kidney biopsy .
There are other types of lupus kidney disease, including: tubulointerstitial nephritis, vascular disease (including thrombotic microangiopathy), lupus podocyte disease, collapsible glomerulosclerosis, and drug-induced in a few cases Lupus related kidney disease
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