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The discovery of BRD4 protein function marks a key step in the treatment of complex congenital diseases and cancer

 Last Update: 2021-10-22
 Source: Internet
 Author: User

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Neural crest precursor cells differentiate into smooth muscle cells (green; nuclei stained pink)

"Inhibition of BRD4 and a class of proteins to which it belongs has always been regarded as a very attractive area of cancer research

This is an attractive goal, but little is known about it

BRD4 is called the "Swiss Army Knife" of the cell because it can regulate many aspects of gene activation, usually as an active regulatory process that allows certain genes to be activated

Jain's team showed that BRD4's function in genome folding is different from its function of keeping genes on

Jain said: "Inhibitors that block BRD4 may also disrupt the proper folding of DNA in certain cells

Mutations in BRD4 are also related to cohesive diseases, which are a group of congenital syndromes, including Cornelia De Lange syndrome and Roberts syndrome, which usually severely damage and shorten the lives of patients

Jain and his colleagues hypothesized that BRD4 tells new cells how to fold their DNA, thereby turning on the correct genes for that cell type, and hope to prove or disprove this hypothesis in upcoming studies

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