The death rate of this disease is 100%, but its vaccine is fake. What's the conscience?

OA show ('918 '); notice from the State Drug Administration on July 15: Recently, the State Drug Administration organized the inspection team to conduct flight inspection on the production site of Changchun Changsheng Biotechnology Co., Ltd according to the clues The inspection team found that Changchun Changsheng seriously violated the GMP in the production process of freeze-dried human rabies vaccine GHP, GHP, GHP, Changsheng biology started trading yesterday On the news, Changchun Changsheng GMP certificate was withdrawn and rabies vaccine was recalled As of the closing, the company's share price was 22.10 yuan, down 9.98%, with 895000 sealed orders, corresponding to a total market value of 21.5 billion yuan, a decrease of 2.4 billion yuan Today's opening was another down stop, offering 19.89 yuan GHP GHP Changsheng released an apology and said all the vaccines in question had been recalled GHP in the morning of July 16 Changsheng released an announcement that Changchun Changsheng recalled all batches of freeze-dried human rabies vaccine within the validity period "Changchun Changsheng is very sorry for this incident Changchun Changsheng will closely track the progress of the incident, actively cooperate with the State Drug Administration, Jilin food and Drug Administration and other relevant regulatory departments to carry out follow-up work, and strictly perform the obligation of information disclosure in accordance with the relevant provisions of the CSRC and Shenzhen Stock Exchange Please pay attention to the investment risks " The reason for GHP GHP fraud is unknown, and whether it affects the quality remains to be further confirmed According to the report of China Securities Journal, Zhao Chunzhi, managing Secretary of Changsheng biology, said that, The sales revenue of freeze-dried human rabies vaccine accounts for about half of Changchun Changsheng's total revenue This incident does not involve other vaccine products of the company Now, the specific reasons for record fraud in the production of freeze-dried human rabies vaccine are unknown, waiting for the investigation results of relevant departments In response to the withdrawal of GMP certificate from GHP, Zhao Chunzhi said that the company could reapply for GMP certificate after the investigation results and rectification GHP, however, "re application for GMP certificate is short for one or two months, long for half a year." According to Shi lichen, founder of Dingchen pharmaceutical consulting Co., Ltd., the production cost of pharmaceutical enterprises will be very high if they produce drugs in strict accordance with GMP requirements, so many pharmaceutical enterprises do not pay attention to drug production and management, and there are various problems The recent revocation of GMP certificates of many pharmaceutical enterprises is a case in point GHP Sina Weibo certified as the @ vaccine and science of microblog 2016 top 10 influential medical big V confirmed the news: the reason for the emergency recall of rabies vaccine of Changchun Changsheng company is said to be that the internal reporting company of Changchun Changsheng company tampered with the production quality data, and the State Food and drug administration took away all computer hosts and mobile phones of relevant personnel GHP GHP an associate professor of Pharmaceutical Engineering in the school of chemical engineering and technology of a well-known university told maomei that there are many kinds of falsification of production records As for whether it has an impact on product quality, it needs to see in what aspects The chairman of GHP Changsheng biology signed an emergency notice to recall the problem vaccine GHP on July 15 An emergency notice from Changchun Changsheng signed by Chairman Gao Junfang came out of the market, and the rabies vaccine produced by the company was recalled The GHP notice requires the provincial promotion team to immediately notify the district and county disease control institutions and vaccination units within the jurisdiction, immediately stop using the company's rabies vaccine, and immediately seal the company's rabies vaccine on the spot GHP GHP, as well as its freeze-dried human rabies vaccine GHP, which accounts for 1 / 4 of the market share, it is understood that Changchun Changsheng Biotechnology Co., Ltd is a wholly-owned subsidiary of the listed company Changsheng Biotechnology Co., Ltd Changchun Changsheng biotechnology official website shows that the company was founded in 1992, is a national high-tech enterprise engaged in the research, development, production and sales of human vaccines, which was listed after the asset restructuring in 2015 According to the 2017 annual report of GHP GHP Changsheng Biology (002680), Changchun Changsheng is one of the first batch of vaccine enterprises that independently develop and sell influenza vaccine and human rabies vaccine (Vero cell) It is one of the few domestic enterprises that can produce virus vaccine and bacterial vaccine at the same time It is the first vaccine enterprise in China that has been licensed to use cell factory technology to produce live attenuated hepatitis A vaccine GHP's 2017 annual report also showed that the company's revenue was 1.55 billion yuan, an increase of 52.60% year-on-year; the net profit attributable to shareholders of listed companies was 560 million yuan, an increase of 33.28% year-on-year Among GHP, vaccine sales accounted for 99.10% of revenue According to the products, the proportion of class II vaccine in revenue is 91.68%, and the gross profit margin of class II vaccine is 90.86% Freeze dried rabies vaccine for human (Vero cell) belongs to class II vaccine, which belongs to self funded vaccination In 2012, the annual revenue of the vaccine (Vero cell) was 24.6083 million yuan, accounting for only 5.7% of the total revenue; in 2013, the revenue of the vaccine dropped to 8.4681 million yuan; but in 2014, the revenue of the vaccine rapidly increased to 212 million yuan, accounting for 34.36% of the total revenue; In the first quarter of 2015, the revenue of freeze-dried human rabies vaccine (Vero cell) reached 73.7089 million yuan, accounting for 47.1% GHP GHP according to statistics, in 2017, Changchun Changsheng's rabies vaccine market volume was 20.78 million, accounting for 1 / 4 of China's market GHP GHP but this is not the first time Changchun Changsheng has been named and reported to GHP on November 3, 2017 The former State Food and Drug Administration issued a report on the disposal of the unqualified products with the titer index of DPT vaccine, saying that the titer index of DPT vaccine with the batch number of 201605014-01 produced by Changchun Changsheng Biotechnology Co., Ltd was found to be unqualified in the drug sampling inspection In response to this, GHP announced that the total sales revenue of the batch of 252600 DPT vaccines was about 833800 yuan In view of the small proportion of DPT combined vaccine in the total sales revenue of the company, the above matters have no significant impact on the current production and operation of the company GHP "the titer index of this batch of DPT vaccine is unqualified, which may affect the immune protection effect, but has no impact on human safety "For the efficacy of this batch of DPT vaccine, the long-lived organism explained this The mortality rate of GHP rabies is 100% Rabies is an acute infectious disease caused by rabies virus Both human and animals suffer from it It is more common in dogs, wolves, cats and other predators People are mostly infected by the bites of animals The clinical manifestations are water phobia, wind phobia, pharyngeal spasm, progressive paralysis and so on Due to the prominent symptoms of hydrophobia, the disease is also called hydrophobia Rabies virus belongs to the genus rabies virus of the family Rhabdoviridae, which is a single RNA virus Animals spread the virus by biting each other In China, rabies is mainly transmitted by dogs, and domestic dogs can become asymptomatic carriers, so dogs with apparent "health" do great harm to human health There is no effective treatment for rabies The mortality rate of people suffering from rabies is nearly 100% Patients usually die of respiratory or circulatory failure within 3-6 days Therefore, preventive measures should be strengthened GHP (author:)