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The marine microbiology team of the Chinese Academy of Thermal Sciences has made new progress in the study of tropical aquatic pathogenic virulence regulators and novel virulence factors, and for the first time reported the role of the important fish pathogenic bacteria Edwardian bacteria EnvZ/OmpR two-component regulatory system OmpR in bacterial stress resistance and pathogenicity, and revealed its regulatory mechanism; The virulence effect and immune escape function
of the novel virulence factor ------ the heptax transmembrane protein YccA were reported.
The research results further promote the elucidation of the pathogenic mechanism of Edwardian amicide and have important theoretical guiding significance
for the study of new ways of aquatic disease prevention and control.
of the novel virulence factor ------ the heptax transmembrane protein YccA were reported.
The research results further promote the elucidation of the pathogenic mechanism of Edwardian amicide and have important theoretical guiding significance
for the study of new ways of aquatic disease prevention and control.
Formerly known as Edwardian bacterium, Edwardiana retarded, it can infect a variety of important economic aquaculture animals such as tilapia, grouper, turbot flounder, causing significant economic losses
in the world's marine and freshwater aquaculture industry.
Edwardiana amicidal bacteria is not only an important pathogenic bacterium in aquatic products, but also a model strain for the study of aquatic pathogenic bacteria, and its pathogenic mechanism research has become a hot topic
in the field.
in the world's marine and freshwater aquaculture industry.
Edwardiana amicidal bacteria is not only an important pathogenic bacterium in aquatic products, but also a model strain for the study of aquatic pathogenic bacteria, and its pathogenic mechanism research has become a hot topic
in the field.
Regulator ompR function studies have shown that knockout ompR significantly weakens the ability of bacteria to resist adversity such as osmotic pressure, acidic pressure, oxidative pressure and antibiotics, reduces the motility of bacteria, and weakens the ability of bacteria to infect host cells and tissues; Regulatory mechanism studies have shown that under normal circumstances, OmpR negatively regulates the acid-resistant system CadBA but loses this regulatory function under acidic conditions, OmpR helps bacteria obtain anti-osmotic pressure ability by positively regulating the outer membrane protein OmpC, and OmpR achieves its regulation of bacterial motility by positively regulating
the flagellar regulator FlhDC.
These results suggest that Eddie Ed.
OmpR is an important regulator that helps bacteria defend against adverse external environments and invasive hosts
by regulating multiple targets.
the flagellar regulator FlhDC.
These results suggest that Eddie Ed.
OmpR is an important regulator that helps bacteria defend against adverse external environments and invasive hosts
by regulating multiple targets.
The study of the mechanism of action of virulence factor YccA showed that knockout yccA significantly weakened the ability of pathogenic bacteria to resist adversity such as high temperature and antibiotics, and greatly reduced the integrity of pathogenic membranes, biofilm formation ability and motility, thereby weakening the pathogen's ability to adhere to host cells and intracellular viability, as well as the ability to infect host tissues.
Studies of pathogen-host interaction have shown that YccA plays an important role
in a series of processes such as pathogenic bacteria escaping serum killing and inhibiting respiratory outbreaks.
These results show that YccA is a new virulence factor of Edwardian arvicidis, which assists pathogenic bacteria to resist the unfavorable environment of the outside world through various channels, escapes the killing of the host, and finally achieves the purpose of
successful colonization in the host.
Studies of pathogen-host interaction have shown that YccA plays an important role
in a series of processes such as pathogenic bacteria escaping serum killing and inhibiting respiratory outbreaks.
These results show that YccA is a new virulence factor of Edwardian arvicidis, which assists pathogenic bacteria to resist the unfavorable environment of the outside world through various channels, escapes the killing of the host, and finally achieves the purpose of
successful colonization in the host.
The results of the OmpR-related study were published in the journal JCR I, Chinese Academy of Sciences, under the title "TCS response regulator OmpR plays a major role in stress resistance, antibiotic resistance, motility, and virulence in Edwardsiella piscicida" Aquaculture》
。 Huo Xiaoping, a master's student jointly trained by the Institute of Biology of the Chinese Academy of Thermal Sciences, and Du Chunmei, a doctoral student, are the co-first authors of the paper, and Hu Yonghua, a researcher at Zhanjiang Experimental Station, is one
of the corresponding authors.
The research was funded
by the Hainan Innovation Team Project and the China Academy of Thermal Sciences Innovation Team Project.
。 Huo Xiaoping, a master's student jointly trained by the Institute of Biology of the Chinese Academy of Thermal Sciences, and Du Chunmei, a doctoral student, are the co-first authors of the paper, and Hu Yonghua, a researcher at Zhanjiang Experimental Station, is one
of the corresponding authors.
The research was funded
by the Hainan Innovation Team Project and the China Academy of Thermal Sciences Innovation Team Project.
The YccA-related research results were published in Fish and Shellfish, a region I journal of the Chinese Academy of Sciences, under the title "Edwardsiella piscicida YccA: a novel virulence factor essential to membrane integrity, mobility, host infection, and host immune response.
" Immunology》
。 Jin Mengru, a master's student jointly trained by the Institute of Biology of the Chinese Academy of Thermal Sciences, is the first author of the paper, and Assistant Researcher Gu Hanjie is one
of the corresponding authors.
The research was supported
by the Hainan Youth Science Foundation Project and the China Academy of Thermal Sciences Innovation Team Project.
" Immunology》
。 Jin Mengru, a master's student jointly trained by the Institute of Biology of the Chinese Academy of Thermal Sciences, is the first author of the paper, and Assistant Researcher Gu Hanjie is one
of the corresponding authors.
The research was supported
by the Hainan Youth Science Foundation Project and the China Academy of Thermal Sciences Innovation Team Project.
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