The Chinese Academy of Sciences team found a new mechanism for food intake and weight control or to help lose weight

Beijing BEIJING, March 8 (Reporter Sun Zifa) correspondent 8th from China Kexue Yuan Institute (Genetics and Developmental Biology Zhong Keyuan Genetics and Developmental) was informed that the John Speakman (John Speakman) research team It is newly discovered that mTOR signal mediates the regulation of low-protein food on food intake and body weight in mice.

This scientific research paper with important translational biological significance was recently published online in the international professional academic journal "Cell-Metabolism".

Zhong Keyuan Genetics and Developmental said that the human diet including protein, fat and carbohydrates three kinds of macronutrients.

In the early days, many scholars believed that dietary fat or carbohydrate content was the key factor leading to obesity.

John Speakman’s research team revealed in previous studies that fat in food is the culprit responsible for obesity in mice, and found that low-protein content (5%) food did not lead to food intake and weight gain.

The first author of the paper, in Keyuan Genetics and Developmental Boshihouwu British Ga said, more interesting is that, despite the transcriptome data analysis showed that 1% low protein treatment resulted in the hypothalamus in mice hunger pathway is activated, but the food intake It did not increase, and there was no overeating phenotype that appeared when calorie restriction (CR) treated mice were re-fed with normal food.

To further verify this hypothesis, the research team used intraventricular injection to target the mTOR signaling pathway in the hypothalamus, confirming that the phenotype that low protein causes lower body fat partly depends on the mTOR signaling pathway and has nothing to do with other signaling pathways.

Papers corresponding author, Zhong Keyuan Genetics and Developmental and Zhong Keyuan Shenzhen Institute of Advanced Technology researcher John Speakman said the latest research presented the possibility that the drug can inhibit the mTOR signaling by means thus weakening diet restriction The hunger and excessive appetite caused by weight loss may help people scientifically lose weight through dieting.