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The cause of liver fibrosis is found!

 Last Update: 2022-10-01
 Source: Internet
 Author: User

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The liver is the most important organ responsible for processing everything we ingest, from food and drink to alcohol and drugs
.

"In the case of liver disease, bile duct cells are damaged," said
Dr.

In a paper published in the journal Nature Communications, they describe a molecule called NIK, which is highly activated
in malfunctioning bile duct cells.

Rui said, "When you remove it, you're preventing all those bad things from happening
.

How does NIK cause disease? Under normal circumstances, NIK promotes the regeneration of bile duct cells in response to various toxic substances
that the liver is exposed to in the performance of its normal duties.

The team hopes to work with collaborators at the University of Michigan and elsewhere to develop new NIK inhibitors to shut down this scarring process
.

Biliary NIK promotes ductular reaction and liver injury and fibrosis in mice

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