The aggressiveness of SARS-CoV-2 can be changed by adding or removing sugar molecules to the protoprotein

May 26, 2020 /PRNewswire
BIOON/ -- Scientists have been tracking thegeneticcomposition of new coronaviruses to better understand the mechanisms of viral spread, so researchers analyzed the association between patient hyperglycemia and disease severity, thus providing new ideas for revealing the infection mechanisms of different types of viruses, specifically, the presence of glycomolecules in viral protoproteins can help effectively distinguish between different types of virusesPhoto source: CDC/DrFred Murphy; Sylvia Whitfieldmany researchers note that many people with high blood sugar sit back with neo-coronavirus in hospitals, whether by peoplea history of diabetesor in patients with unexplaineddiabetes, which may indicate that the virus molecule is added to additional sugar molecules, or that receptors attached to infected cells can affect the severity of the diseaseThe author, aoncologist
from the University of Pittsburgh who studies how to treatpatients withbreast cancer, is currently conducting trials using the drug hydroxychloroquine to block the growth of breast cancer in the bone marrow researchers speculated that adding extra sugar molecules to the virus's outer membrane and its receptors might explain the severity of the disease caused by the new coronavirus infection, so researchers were very interested in studying whether mutations in the virus would add or decrease molecules from viral proteins to increase or decrease the severity of the disease; sequencing and mutation scanning of new coronaviruses unlike previous pandemics, 2020 The researchers have acquired a new and powerful tool that allows researchers to obtain RNA sequences of viruses in real time and track changes in viruses as they move from one place to another; these coronaviruses do change considerably, and scientists at the international research organization GISAID have been working on the virus mutations, which they have created, and the next strain website they created is open Information and resources are available to anyone image source: Adam Brufsky, CC BY-SA When researchers looked at the database, they found that there appeared to be a common mutation in an identified protoprotein covered on the surface of the virus, a special region of the virus, which, when replicated in the host cell, added sugar molecules to the virus surface, and the mutation appeared to increase the likelihood that sugar molecules would be added to the region, and similar mutations on other coronavirus protoproteins might affect the integration of these viruses with host cells interesting, the mutation, called D614G, appears to be more common on the East Coast of the United States than on the West Coast, and the disease appears to be more serious on the East Coast; although the causal link between the mutation and the severity of the disease has yet to be further confirmed, it can at least partially explain the difference between the severity of the disease on the East coast and the West Coast; Other mutations of the new coronavirus protrusion protein isolated in the body may alter the toxicity or aggressiveness of diseases in cells in the laboratory; for example, the Wuhan SARS-CoV-2 strain, which is more similar to the strains in Washington and California, is less invasive than the strains in cell cultures (similar to those in Europe) Although this is only a theory, it means that SARS-CoV-2 is trying to try to co-exist with humans, if a virus is too invasive, it may not spread on its own by sending too many infected people to hospital; Scientists from all over the world are now trying to solve this problem, and the clinical observations they have received are interesting (BioValleyBioon.com) References: , Blood Glucose Levels in Elderly Subjects with type 2 diabetes during COVID-19 outbreak: a-study in a single center
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