The Age of Nucleic Acid for All and Our Reshaped Life

Nucleic acid testing is starting to become as important as sunlight, air and wat.

In the beginning, it was traveling between different cities, entering and leaving the airport and train station, then hospitalized for medical treatment, and then by subway and bus, shopping malls, librari.

When the epidemic prevention policies in various places cut society into square grids, the nucleic acid negative certificate has become a pass for ordinary people to strive to maintain a normal li.

Losing "48 hours" of nucleic acid has proved to be easy to feel a strong sense of unease, and doing nucleic acid at public service points has become a conditioned refl.

People are accustomed to making nucleic acids, as natural as they are used to wearing masks and showing the health code itinerary co.

Beijing, Shanghai, Shenzhen, Hangzhou, Jiangsu, Nanchang, Wuxi, Yanche.

This national nucleic acid testing campaign has risen to the height of the country: thousands of "nucleic acid sampling booths" have sprung up, and high-throughput, automated nucleic acid laboratories have been urgently complet.

The impact of the new coronavirus on humans is long-te.

Defend the nucleic acid code: During the May Day holiday, I did 9 nucleic acid tests

After completing the ninth nucleic acid, K's holiday breakthrough finally came to an e.

This May Day, our friend K is going from Suzhou, Jiangsu to Zhanjiang, Guangdong to attend his friend's weddi.

On normal days, K would take the train first and then take a plane to a neighboring city, but the April epidemic in Suzhou made K a star lead.

Under the epidemic, most transit places will be taken away and quarantined as soon as they leave the train stati.

Immediately after that, K began to "card point" matching the nucleic acid certification time with the ticket ti.

Before arriving in any city, K will make at least three calls: city health service hotline, airport/train station, hot.

The 48-hour nucleic acid test has become a standard for many cities, and a few cities that accept personnel with stars will require the nucleic acid detection time to be further shortened to within 24 hou.

For departure, transit, and arrival, K must ensure that the nucleic acid certificate is within 24 hours at each link, and every time he arrives in a city, he must immediately prepare a local nucleic ac.

K will prepare two nucleic acid copies at any time, a 24-hour report that has been issued, and a report waiting for the test results, because the previous nucleic acid is likely to expire when it arrives at the destinati.

Once the nucleic acid was done the night before and it was still within the validity peri.

The next morning, a community member came to the door and asked to go to the designated place to do the nucleic acid again on the same d.

Every time he sees a sampling point, K will not let it go, because he must constantly ensure that the nucleic acid is within 24 hours, "one more nucleic acid, one more peace of min.

Not only K, since this year, almost everyone who needs to travel has been defending the nucleic acid co.

From south to north, these cities are connected by a line of economic corridors in Chi.

From entering and leaving each city, nucleic acid certificates are required, and when entering and leaving local public places, nucleic acid certificates are also requir.

The validity period of nucleic acid is constantly adjusted according to the epidemic situation in the local and neighboring citi.

A new management method was quietly bo.

Following the red, yellow and green codes, starting from April 15, Wuhan has assigned gray codes to those who have not participated in the inspecti.

Beijing HealthCare will use a pop-up window to remind people to participate in nucleic acid testi.

The health codes in many cities will highlight the timeliness of nucleic acid testi.

"24", "48", "72", the bright numbers are very eye-catchi.

A public relations practitioner in Shenzhen said that when entering an office building, returning to the community, and various public places, he must read nucleic ac.

As long as he loses the 48-hour nucleic acid certificate, he will have a strong sense of insecuri.

A Dalian university student introduced that each nucleic acid record must be uploaded to the "Today's Campus" APP, otherwise the counselor will talk to him, and even teaching will give way to nucleic acid testi.

The group chat was also captured by nucleic ac.

The leaders said "tomorrow, again, familiar process", and the members started the nucleic acid solitaire like a robot the next d.

If it is missed, life will be out of ord.

At the end of April, a university in Wuhan canceled the sampling of the original two-day inspection due to heavy ra.

The students of the entire school became gray codes that day, and supermarkets, libraries, stadiums, and campuses could not ent.

Due to the increasing number of people accumulating at the door, the security guards had to ignore the health code requirements to be releas.

People have become accustomed to doing nucleic acid testing like clockwork every day, worrying that one day they forget to participate, cannot go out, and affect their wo.

Not only the school or unit requirements, but also the normal entertainment life needs to plan nucleic acid in advance, even if it is a movie, a meal, a fitne.

Infrastructure Competition: Create a 15-minute nucleic acid service circle

Previously, the sampling site was a place with a blue tent and a brown de.

Over the past two years, they have slowly spread from hospitals and took root in subway stations, residential areas, office buildings, business districts, parks, and squar.

At the beginning, after a period of nucleic acid testing is completed, the blue tent will be withdra.

Later, due to the increase in the frequency of use, the tent and tables and stools simply stay in pla.

Some leisurely people began to hang a small lamp under the tent at night, put together several tables, and played mahjo.

As a landscape, the sampling site is successfully integrated into public li.

Tianfeng Securities' "Normalized Nucleic Acid Detection and Sorting" report pointed out that according to the daily load of 3,000 people at sampling points, a city with a population of 20 million needs to set up 6,667 sampling poin.

In China, there are 18 cities with a population of over 10 million, and 91 cities with a population of over 5 milli.

Sampling points are spread out like an "arms rac.

Beijing Fengtai has opened 1,065 sampling points, Wuxi has 2,600, and Shanghai and Hangzhou have plans to set up 9,000 and 10,000 respective.

Local government new media platforms or map APPs can query nearby points, nearby detection, and some small mobile sampling points, which together constitute the "new infrastructure" of the national nucleic acid e.

More and more cities are beginning to deploy sampling booths, which are fully enclosed, temperature-controlled and wind-regulated containers, and have a deceptive name—healthy hu.

Compared with tents, health huts are not affected by weather and ti.

When nucleic acid testing has changed from "emergency" to "normal", the hospitals that were originally responsible for emergency sampling are struggling to balance daily diagnosis and treatment and support tas.

According to the "Regional Novel Coronavirus Nucleic Acid Detection Organization Implementation Guidelines" issued in March, it is recommended that "a sampling table is rotated by 2 people, and each person samples 120 people per hour", and the number of nucleic acid sampling personnel = the number of population ÷ 360.

According to the data of the seventh census, the total population of all first-tier, new first-tier and second-tier cities in China is about 510 million, and a total of about 4 million samplers are need.

A staff member of a community health center in Xihu District, Hangzhou told Badian Jianwen, "In the past, the two communities fought for one point, but after normalization, many testing points were allocated at once, and now the manpower is very tig.

"

A medical worker in Beijing introduced the situation of his department, "One day the front-line doctor and the next team could not come to the hospital due to the pop-up wind.

Many doctors in the hospital, including the director-level doctor, went to support the nucleic acid test, and the left-behind took on more burde.

workloa.

In order to make up for the sampling gap, many hospitals and third-party testing centers in Shenzhen, Hangzhou and other places offered high salaries of "300-500 yuan per day" and "monthly income over 10,000" to recruit samplers from the socie.

On May 4, the Health and Health Commission of Shunyi District, Beijing posted on its official account that the recruited "volunteers come from all walks of life, including members of the Blue Sky Rescue Team, campus students, and retired 'Shunyi Aunt.


They participated in the nucleic acid sampling work after passing the assessment and traini.

"

After recruiting 10 sampling volunteers, the above-mentioned community health center in Xihu District "can basically maintain normal diagnosis and treatment wo.

During the day, the volunteers are responsible for sampling, and the in-service employees go off work at night to rota.

"

A maternal and child health hospital in a certain district of Wuhan gradually worked out a set of ingenious arrangements for support staff, "When there is an epidemic, the number of visits to the hospital's cosmetology department and traditional Chinese medicine department will drop significant.

We will first deploy support teams from these departments and wait for the epidemic to pa.

, the department gradually has patients, and we will transfer these people ba.

"

Although according to the guidelines, each sampling station can collect samples from 120 people per hour, in the limited cases learned by 8:00 Jianwen, some samplers can collect two or three hundred primary school students in about half an hour to an hour, and some "experienced" "A total of 1,200 people were collected in 4 hours in the morning, but if the door-to-door sampling encountered an old community with a complex structure or no elevators, "one person will collect 12 people in the morni.

"

It is not easy to evenly distribute sampling resourc.

In some old residential areas, there are many elderly people, and the sampling sites are often idle; while in modern high-rise residential areas, it is often necessary to queue for an ho.

It is basically difficult for small cities to maintain a huge system of "sampling and testin.

Huang Jia (pseudonym), who went to Shenzhen from his hometown in Guangdong, encountered nucleic acid congestion for the first ti.

The town health center's testing capacity can only sample key populatio.

Huang Jia, who came from a low-risk area, needs to go to a city-level designated hospit.

It took an unprecedented one and a half hours to complete the nucleic ac.

You know, he did 38 nucleic acid tests in Shenzhen in March and April, and each time did not exceed 20 minut.

The fastest time was "do it and g.

What supports the normalized nucleic acid detection in units of 100 million?

The other end of the "infrastructure maniac" is the rapid expansion of testing laboratori.

However, compared with the sampling end, the changes at the detection end are not drast.

The air film laboratory, the square cabin laboratory, and the PCR instrument have been uniformly deployed to fill the g.

Inspectors are recruited temporarily and replaced by automated equipme.

In the distant May 2020, when Wuhan first proposed the "Ten-Day Battle" for national nucleic acid testing, no one expected that China's testing capabilities would undergo a qualitative leap in just two years, with about 15 billion complet.

Human nucleic acid testi.

The relevant person in charge of the National Health and Medical Commission said in an interview with the media, "At present, only China in the world can quickly find the source of infection, cut off the transmission route, and quickly control the epidemic through large-scale population nucleic acid testi.

"

According to the China Disciplinary Inspection and Supervision News, as of mid-April, China had 13,100 medical institutions conducting nucleic acid testing for COVID-19, with nearly 150,000 technicians and a testing capacity of 565 million tubes per d.

There are also 100 public testing laboratories, 820 third-party laboratories and 780 urban testing bas.

The price of testing has dropped again and aga.

The single-tube testing in Beijing, Hebei and other places has dropped from 28 yuan per person to 17 yuan, and the maximum price of mixed testing has dropped from 6 yuan per person to 4 yu.

Many urban communities can still be fr.

.

In the recent 18-province coalition centralized collection, the detection reagents appeared at 2 yuan per copy, shocking the industry's "ultra-low price" and "very thin profi.

A number of sales staff told 8:00 Jianwen that local governments have centralized control and deployment of several brands of PCR instruments in order to ensure the supply of instrumen.

After the resumption of work and production, the prices of equipment and sampling booths in the market are all reduc.

Beijing, Nanjing, Shanghai and other places are still urgently expanding testing laboratori.

In March, Shenzhen set up nucleic acid testing laboratories at 9 railway stations and 1 airport in the ci.

During large-scale testing, testing personnel also need to be dispatched to support from the testing departme.

Generally, the unit of calculation of laboratory testing volume is "24 hour.

8:00 Jianwen learned that the budget for adding a prescription-chamber laboratory generally starts at 800,000 yuan, and the price of a three-chamber air-film laboratory is about 600,000 yu.

The market price of some key equipment such as a 96-hole PCR instrument is also over 100,000 yu.

Chen Weijun, Chief Scientist of Infectious Diseases at BGI and a professor at the University of Chinese Academy of Sciences, told 8 Jianwen that the current process from extraction to nucleic acid amplification is highly automated, and in the process of large-scale detection, the use of automated equipment will also reduce costs, " However, the sample sorting before the extraction-amplification procedure can only be done manually, and the sorting process of a batch of samples may take 2-3 hours, while the automated extraction and amplification process only takes more than 1 ho.

”

"More expensive is the labor cos.

The monthly salary offered by various places for laboratory personnel ranges from several thousand to tens of thousan.

In Shanghai, where the number of inspections has increased sharply, the salary offered by a three-party inspection agency for short-term and long-term inspectors is "1500-2000 yuan/da.

According to the calculations of Tao Chuan, chief macro analyst of Soochow Securities, and others, the annual cost of normalizing full-staff nucleic acid in all first- and second-tier cities is about 670 billion , and 490,000 related jobs can be added based on 72-hour nucleic ac.

However, in cities with free and normalized testing, the cost is dominated by one-way capital inflow, and is generally borne by medical insurance and finan.

It is still difficult to detect the quality and grasp the strength and accuracy of contr.

On April 22, Chaoyang District, Beijing, where the first cases of infection were discovered, announced on May 6 that “sporadic cases of transmission still exist in society after banning dine-in, controlling the rate of building attendance, and implementing home office for all employe.

It has not been completely blocked, and a new round of regional nucleic acid testing will contin.

"

Since April, medical staff and nucleic acid samplers have been infected in Shanghai, Hunan, Anhui, and Beiji.

The Beijing Health and Health Commission recently reported that several cases of infected persons with respiratory symptoms were still negative for nucleic acid testing, and during the flight supervision and inspection, it was found that individual nucleic acid testing institutions have not submitted timely inspections, reported inaccurately, and laboratory management was not stri.

and so .

Virology expert Chang Rongshan analyzed, "The reason why the nucleic acid test is still negative after symptoms appear, first of all, individual differences, they are 'random weak infectors'; secondly, due to vaccination, the virus shedding time of infected people is short, the virus The load is low; in addition, the more common reason is that the mixed detection leads to a decrease in the detection efficiency, especially when the nasopharyngeal swab is sampled, the improper operation leads to the poor quality and insufficient quantity of the collected human respiratory epithelial cel.

”

Chen Weijun told 8:00 Jianwen that it is not scientific to use Ct value to judge whether it is infectio.

Currently, convalescent patients with Ct value ≥ 35 show that they are not infectious, but for patients who are infected and progressing, Even if the Ct value is ≥35 and the nucleic acid is negative, the virus will continue to replicate in the following time, and the host may infect othe.

Different kits also have different determination criter.

If the so-called Ct is less than or equal to 35 (to determine infection), it will also bring the possibility of "false negativ.

The person in charge of the medical department of a community health center in Wuhan believes that "(the sampling volume) greatly exceeds the guideline figures, which means that either his sampling is not standardized or the disinfection is not done we.

" But as long as there are no positives, no one will investigate the sampling quali.

A bubble society connected by "nucleic acid"

The epidemic and nucleic acid detection seem to be reshaping the entire social ecology by a new set of breathing metho.

Ubiquitous nucleic acid testing is re-weaving collective memo.

From the city to the countryside, from the inland to the island, from the old to the young, whenever there is a case in a certain place, even the elderly who stay at home and the young children who are babbling, are required to participate in this nucleic acid Detect moti.

Normalized nucleic acid has drawn more people into this ecosystem, and cities, large and small, countless social organizations and people have been involved in this moveme.

After the May Day holiday, K became more accustomed to this "nucleic acid lif.

"After all, a negative certificate can give you a certain limit of freedom during this new crown pandemic peri.

"

Goldman Sachs Chief China Economist Shan Hui and the macro research team believe that "although normalized nucleic acid testing measures cannot be a 'panacea' to completely contain the epidemic, they can alleviate and restrict the epidemic or large-scale lockdown measures within a certain period of ti.

Disruption and impact on China's manufacturing industry and the overall econo.

"

"Omicron is passed down from generation to generation in two or three da.

Normalized nucleic acid testing can at least ensure early detection, and the high probability of detection is not strong and the scale of the epidemic is sma.

" Shopping malls are compared to large and small bubbles, "Normalized nucleic acid can quickly detect abnormal bubbles and eliminate them, residents with negative certificates can resume work and life, and those without certificates cannot enter other places, thus isolating the risk of infection in the bubbl.

Interna.

The whole society is like a world constructed by countless bubbl.

Big bubbles connect every city in the country, and within each city, small bubbles connect every dense public pla.

Between cities and in personal life circles, there are different bubbles that require a "nucleic acid passport" to enter another bubb.

According to the situation of the epidemic, the gap between the bubbles will be tight and loose, and the validity period of nucleic acid will also be compressed or extend.

For example, when there is an epidemic in the surrounding area, the nucleic acid pass is often required for 24 hou.

When the local epidemic situation and the epidemic situation in surrounding cities improve, the effective time of nucleic acid is also relaxed from 24 hours and 48 hours to 72 hou.

When a city has high-risk areas, it is only allowed to enter another bubble as a safe individual after spending a certain amount of time in the "middle zone" isolation poi.

Every city is creating different slogans for the arrival of the national nucleic acid era - "Fight the epidemic with one heart, protect the green code", "Leave a person, seal a city", "Press the slow travel button in the city, and the anti-epidemic starts to accelera.

.

A person's "Negative Nucleic Acid Certificate" at the moment is a passport, a group of people's negative certificate is a low risk and a sense of psychological security, and a city's negative certificate for a period of time means that everyone in the city will get some valuab.

A space for normal living, although it is not known how long it will la.