The advantages of MRI and 5-ALA technology in HGG excision

Glioma is the most common type of primary central nervous system (CNS) tumorHigh-level glioma (HGG) has a poor prognosisTumor excision range (EOR) is a key factor affecting the prognosis of patients, eOR and total survival, quality of life, malignant transformation, seizure, function duration, etcare positively correlatedInoperative MRI imaging and fluorescent staining imaging can overcome the brain displacement restriction of traditional imaging navigation, improve the rate of removal, and prolong the progression-free survival time of glioma patientsDanielle Golub, of The University of New York School of Medicine' Neurosurgery, and others, conducted a systematic review of improving effective EOR in HGG surgery using quantitative network meta-analysis, analyzing associated progression and overall survival rates, published online in February 2020 in J Neurosurgresearch methods
11 related literatures were selected for this studyIn HGG excision, the conventional stereotactic navigation technology under white light was used as a control group, IMRI and 5-ALA technology were compared with traditional navigation, and the effects of IMRI and 5-ALA technology were compared to determine the advantages and disadvantages of using IMRI and 5-ALA technology to control the scope of glioma excisionA meta analysis found that IMRI technology was superior to conventional stereotactic navigation in adult HGG total excision (GTR), and IMRI technology extended patient severity without progress and total survivalMeta analysis comparing 5-ALA technology with traditional navigation techniques found that the use of 5-ALA significantly increased the likelihood of glioma GTRThe Higgins test showed that the results of the 5-ALA technology were of limited heterogeneityTwo studies of HGG patient survival prognosis including RCT showed that 5-ALA technology was used to improve progressionless survival and overall survival rates in patientsNetwork meta-analysis suggests that the use of IMRI and 5-ALA technology in HGG excision has no obvious advantages and disadvantages in HGG GTR, with slight advantages tending to IMRIHowever, careful consideration of the potential bias risks in retrospective studies and the increased heterogeneity of IMRI technology research findings are likely to suggest that the IMRI technical effects are artificially increasingTherefore, the author believes that IMRI technology and 5-ALA technology are equally effectiveThe cost of 5-ALA technology is about half that of IMRI conclusion
the authors believe that, compared with the application of conventional stereotactic navigation technology, the use of IMRI and 5-ALA technology can individually show superiority for HGG excision rate and survival Comparing IMRI with 5-ALA technology, it is found that the two intervention methods in the GTR of HGG are not in the same way But both are superior to the traditional imaging navigation techniques alone.