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Tetrabenazine tablets are approved soon for the treatment of Huntington's disease

 Last Update: 2021-06-22
 Source: Internet
 Author: User

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Recently, Shandong Bausch & Lomb Furuida Pharmaceutical Co.
, Ltd.
has entered the administrative stage for the import application of the 5.
1 new drug tetrabenazine tablets (the relevant acceptance number is JXHS2000123/124), and it is expected to be officially approved soon and become the second domestic approval.
Huntington's disease (HD) treatment drugs
.

Tetrabenazine (Xenazine) is a vesicle monoamine transporter 2 (VMAT2) inhibitor, which reversibly inhibits VMAT2 in vivo through its dihydroxy metabolites (HTBZ) α-HTBZ and β-HTBZ.
Role
.

The drug was originally used to treat schizophrenia.

In China, tetrabenazine was included in the "List of the First Batch of Clinically Needed New Drugs Abroad" issued by CDE in 2018, and will be reported for domestic production in August 2020
.

Once officially approved in the future, tetrabenazine will become the second HD drug approved in China after deuterated tetrabenazine

In addition to the above two drugs, there are currently several HD drugs under development abroad, such as Roche's tominersen (RG6042, also called RO7234292), UniQure's AMT-130, and Voyager Therapeutics' VY-HTT01

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