Tea polyphenols in green tea can significantly improve the efficacy of anticancer drugs

Hepatology, the latest international authoritative journal of Hepatology, published a research in the form of cover article, which was completed by the State Key Laboratory of genetic engineering of Fudan University and Johns Hopkins University School of medicine This study points out that green tea has a significant detoxification effect on the toxic and side effects of anticancer drugs When cancer patients take the clinical first-line anticancer drug daunorubicin (DNR) and drink more green tea at the same time, their efficacy will be greatly improved Yu Long, one of the project leaders and professor of the State Key Laboratory of genetic engineering of Fudan University, said that daunorubicin is a widely used anticancer drug at present However, daunorubicin will combine with carbonylreductase 1 (cbr1), an enzyme widely existing in the human liver, which will not only reduce its antitumor activity, but also produce toxicity to the heart, causing damage to myocardial cells Wound This metabolic characteristic of daunorubicin greatly limits its clinical application In the research on the anticancer effect of green tea, the researchers found that the main component of tea polyphenols in green tea has a good inhibition on carbonyl reductase 1, which means that it can reduce the side effects of daunorubicin and improve its clinical efficacy The findings not only reveal a new way of liver cancer treatment, but also provide new ideas and data for further systematic analysis of drug resistance, reduction of drug toxicity and side effects, and discussion of drug combination in tumor treatment Generally speaking, tea can play a positive role in the efficacy of the anticancer drug, but due to different fermentation methods, the content of tea polyphenols in green tea is higher, and the effect of drinking more green tea will be better, Yu said.