TB bacteria cause disease and are the culprits.

Recently, Tongji University School of Medicine, Tongji University affiliated with Shanghai Lung Hospital Professor Gobao science team in cooperation with Shanghai University of Science and Technology Rao Zi and academician team found that TB bacteria have a protein is very "smart", it can use the body's protein molecules to attack their own immune system, resulting in tuberculosis. The results were published online January 16 in Nature.
So far, the incidence and drug resistance mechanisms of TB bacteria are not fully possible, there is a lack of rapid and accurate diagnosis of tuberculosis, and the lack of new drugs makes TB prevention and treatment still face great challenges.Dr. Wang Lin of Shanghai Lung Hospital, affiliated with Tongji University and co-author of the
paper, said the team studied the structure, function and regulatory mechanisms of key pathogens and host molecular machines in the course of TB infection and disease- and disease-related infections, and developed new anti-tuberculosis drugs around the key issue of "the interaction between TB bacteria and hosts is the basis for infectious diseases". The study found that when the human body infected with TB bacteria, TB bacteria can secrete the toxic factor Rv0222, and Rv0222 using the body's protein modification system, after secondary processing can effectively resist attacks from the body's immune system, resulting in TB bacteria from the body's immune system escape and disease.
Zhao Guoping, a member of the Chinese Academy of Sciences, and Xiao Ping, chief clinical adviser for tuberculosis at Shanghai Lung Hospital affiliated with Tongji University, both said that the study fully expounded the escape mechanism of TB bacteria using human ubiquinin system to resist human immune attacks, and broadened our vision of the role of protein modification systems in the regulation of infectious diseases. At the same time, through protein structure analysis and functional exploration, the researchers accurately pointed out that Rv0222 toxic protein is in its 76-bit lysine after ubibin modification to play a toxic force, can be in subsequent studies for the development of new anti-tuberculosis drugs to provide a more accurate target. (Source: Huang Xin Zhang Shuanghu, China Science Journal)
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