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Targeting ZNF117 induces differentiation of GBM stem cells into oligodendrocyte lineage

 Last Update: 2022-08-20
 Source: Internet
 Author: User

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Jun Liu et al.

- excerpt from article chapter

【Ref: Liu J, et al.

Research Background

Glioblastoma (GBM) has a poor prognosis with an overall 5-year survival rate of less than 4%

The authors first employed a genome-wide RNAi screen to identify genes that regulate the survival and differentiation of GSCs

Research result

Trajectory analysis of single-cell sequencing revealed that ZNF117 could regulate the differentiation of GSCs to the oligodendrocyte lineage

Transcriptome analysis of ZNF117 knockout cells showed that ZNF117 regulates Notch signaling; pathway enrichment analysis suggested that Notch activity was down-regulated in ZNF117 knockout cells

This study revealed that ZNF117, as a regulator of GSCs differentiation, could be a target for GBM therapy

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