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Targeting microglia in the brain may help prevent and treat Alzheimer's disease

 Last Update: 2022-02-25
 Source: Internet
 Author: User

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In a new study, researchers from Weill Cornell Medical College have discovered that a genetic mutation linked to Alzheimer's disease alters signaling pathways in certain immune cells in Alzheimer's patients

The study focused on microglia, the immune cells in the central nervous system that are the first to respond when something goes wrong in the brain

Alzheimer's disease is the most common neurodegenerative disease of aging, affecting approximately 46 million people worldwide

Single-cell RNA-seq analysis of microglial responses in a mouse model of Alzheimer's disease

Image via Science Translational Medicine, 2021, doi:DOI: 10.

To study how microglia in the brain might contribute to Alzheimer's disease, Dr.

Importantly, since AKT signaling also contributes to the pathogenesis of many types of cancer, MK-2206 is currently being evaluated in multiple cancer clinical trials

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References:

Faten A.

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