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Targeting IL-4R monoclonal antibody (AK120) to treat atopic dermatitis and asthma, China Phase II clinical trial has been launched

 Last Update: 2021-10-19
 Source: Internet
 Author: User

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Akeso pharmaceutical company announced that its drug candidate anti-IL-4R monoclonal antibody (AK120) has received Chinese State Drug Administration approved the Board Center for Drug Evaluation (CDE) of, II clinical trials for the treatment of moderate to severe asthma to launch in China

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At the same time, the global phase II clinical trial of AK120 for the treatment of moderate to severe atopic dermatitis completed the first patient enrollment at the first research center in the United States

IL-4 and IL-13 are two key factors that cause type II inflammation

In terms of safety, the single-dose escalation phase Ia clinical trial of AK120 in healthy subjects for the treatment of atopic dermatitis and the multi-dose escalation phase Ib clinical trial of AK120 in the treatment of atopic dermatitis have been completed in New Zealand and Australia

In terms of efficacy, early clinical trials have shown that AK120 has a potential clinical efficacy comparable to or better than dupilumab in patients with atopic dermatitis

Anti-IL-4R monoclonal antibody is considered to be an important target for the treatment of allergic diseases

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