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Scientists work in a special hydrogel whose properties can be changed in a controlled way
In summarizing these key findings, Britta Trappmann emphasized, “Synthetic tissue materials must activate certain adhesion molecules on the vascular cell membrane, allowing cells to migrate in groups from the mother’s blood vessel to form a tubular structure
Three-dimensional tissue frame made of hydrogel
In this study, the researchers perfected the model system that Britta Trappmann developed with colleagues when he was a postdoctoral fellow at Boston and Harvard University in the United States
Then, the scientists wanted to find out which properties of the hydrogel determine whether the migrating endothelial cells actually form new blood vessels
Integrin migration
The higher the peptide concentration, the more endothelial cells migrate through the hydrogel
Although blood vessel cells then form tubular structures, they are smaller than in natural tissues
Journal Reference :
Jifeng Liu, Hongyan Long, Dagmar Zeuschner, Andreas FB Räder, William J.
