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    Home > Biochemistry News > Biotechnology News > Synaptic dysfunction in schizophrenia: is it a loss of excitement or a loss of inhibition?

    Synaptic dysfunction in schizophrenia: is it a loss of excitement or a loss of inhibition?

    • Last Update: 2021-09-29
    • Source: Internet
    • Author: User
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    Schizophrenia can lead to thought and mood disorders, delusions and hallucinations, and is one of the most debilitating and mysterious mental disorders


    The nature of the changes in the brain circuits of patients with schizophrenia is not yet clear-is it over-excited or not enough, over-inhibited or not enough, or some combination? In order to find the answer, the research team led by Dr.


    Dr.


    John Krystal, MD, editor of Biopsychiatry, said: "The study of the basic characteristics of synaptic dysfunction in schizophrenia may help guide pharmacology and neurostimulation therapies for the treatment of this disease


     "Computational modeling of EEG and fMRI paradigms indicates a consistent loss of pyramidal cell synaptic gain in schizophrenia," by Rick Adams, Dimitris Pinotsis, Konstantinos Tsirlis, Leonhardt Unruh, Aashna Mahajan, Ana Montero Horas, Laura Convertino, Ann Summerfelt, Hemalatha Sampath, Hemalatha Xiaoming Michael Du, Peter Kochunov, Jie Lisa Ji, Grega Repovs, John Murray, Karl Friston, Eilliot Hong, Alan Anticevic ( https://doi.



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