Symbic viruses maintain the immune function of the intestinal mucosa

in people's common impression, the virus is harmful to the human body without any harm. In fact, some viruses can be "poisoned" to help human health. Recently, Zhou Rongbin, Jiang Wei and Zhu Shu, professors of the Basic Medicine School of the University of Science and Technology of China, the Key Laboratory of Natural Immunity and Chronic Diseases of the Chinese Academy of Sciences and the National Research Center for Microscale Matter Science in Hefei, were the first to discover that symbic viruses in the intestine play an important role in maintaining intestinal immune stability, and revealed the cellular and molecular mechanisms in which they play a role. The findings were published in Nature -Immunity on October 21.
large number of symbic microorganisms, including bacteria, viruses and fungi, in the human intestine, lungs, skin and other tissues. Numerous studies in recent years have shown that these symbic microorganisms have become part of the human body and play an important role in many normal physiological functions and the occurrence of almost all diseases. However, in the past, almost all studies have focused on symbiotic bacteria, and there is a lack of research on the pathology and physiological function of symbiotic viruses.
intestinal epithelial lymphocytes, as the first line of defense against intestinal mucosa immunity, play an important role in maintaining the balance of the intestinal mucosa. The work found that symbient viruses play an important role in maintaining the steady state of lymphocytes in the intestinal endocyttes, and that reducing symbic viruses can lead to a significant reduction in intestinal endocystral lymphocytes. Further mechanism studies have found that RRNs produced by symboxic viruses can be identified by the inherent immunoreceptors expressed by antigen-presenting cells in the intrinsic layer of the intestine, and further produced by inducing antigen-presenting cells to produce leukocyte interleukin 15 (IL-15), thereby maintaining the survival and proliferation of lymphocytes in the intestinal supersethic. Finally, the work also found that the maintenance of the intestinal symbient virus to the stability of lymphocytes in the upper cortitis helped to inhibit the occurrence of intestinal tissue damage and inflammation.
the study was the first to reveal the role of enterovirus in the maintenance of intestinal immunostatic stability, and to clarify the mechanism, suggesting that intestinal symbient virus imbalance may induce enteritis, bowel cancer and other diseases. (Source: Yang Fan, China Science Journal)
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