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Super antigen molecules can efficiently activate T cells, produce immune killing and immune surveillance on tumors, and are an ideal candidate for immune anti-tumor drugs
.
However, the excessive activation of T cells may induce the production of regulatory T cells (Tregs) with immunosuppressive function.
This is a problem that needs to be revealed and solved in the development of immune anti-tumor drugs
.
The Microbial Resources and Ecology Research Group of the Shenyang Institute of Applied Ecology, Chinese Academy of Sciences, relying on the "Shenyang Key Laboratory of Super Antigen Research", is committed to the research of super antigen theory and research and development of new immune and anti-tumor drugs, and has achieved a series of research results
.
Recently, researchers have confirmed from the molecular and cellular levels that high concentrations of super antigen SEC2 can induce the production of immunosuppressive CD4+CD25+Foxp3+ Tregs, and the induced Tregs highly express CTLA-4, GITR, and low CD127, secreting anti- The inflammatory cytokine IL-10 has typical regulatory T cell-related phenotypic characteristics; it reveals that TCR-NFAT/AP-1, IL-2-STAT5, and TGF-β-Smad3 signals are the main pathways for SCE2 to induce CD4+ Tregs
.
This result helps explain the balance between superantigen-mediated immune stimulation and immunosuppression, and has guiding significance for the future clinical application of superantigens in tumor immunotherapy
.
Related research results were published on Biomedicine & Pharmacotherapy with the title of Induction of CD4+ regulatory T cells by stimulation with Staphylococcal Enterotoxin C2 through different signaling pathways
.
The research work has been supported by the Chinese Academy of Sciences Strategic Leading Science and Technology Special Project (Category A), the Liaoning Province Xingliao Talents Plan Project, and the Shenyang Science and Technology Bureau's Young and Young Technological and Innovative Talent Support Project
.
The phenotypic characteristics and induction mechanism of CD4+ Tregs induced by super antigen Source: Shenyang Institute of Applied Ecology, Chinese Academy of Sciences
.
However, the excessive activation of T cells may induce the production of regulatory T cells (Tregs) with immunosuppressive function.
This is a problem that needs to be revealed and solved in the development of immune anti-tumor drugs
.
The Microbial Resources and Ecology Research Group of the Shenyang Institute of Applied Ecology, Chinese Academy of Sciences, relying on the "Shenyang Key Laboratory of Super Antigen Research", is committed to the research of super antigen theory and research and development of new immune and anti-tumor drugs, and has achieved a series of research results
.
Recently, researchers have confirmed from the molecular and cellular levels that high concentrations of super antigen SEC2 can induce the production of immunosuppressive CD4+CD25+Foxp3+ Tregs, and the induced Tregs highly express CTLA-4, GITR, and low CD127, secreting anti- The inflammatory cytokine IL-10 has typical regulatory T cell-related phenotypic characteristics; it reveals that TCR-NFAT/AP-1, IL-2-STAT5, and TGF-β-Smad3 signals are the main pathways for SCE2 to induce CD4+ Tregs
.
This result helps explain the balance between superantigen-mediated immune stimulation and immunosuppression, and has guiding significance for the future clinical application of superantigens in tumor immunotherapy
.
Related research results were published on Biomedicine & Pharmacotherapy with the title of Induction of CD4+ regulatory T cells by stimulation with Staphylococcal Enterotoxin C2 through different signaling pathways
.
The research work has been supported by the Chinese Academy of Sciences Strategic Leading Science and Technology Special Project (Category A), the Liaoning Province Xingliao Talents Plan Project, and the Shenyang Science and Technology Bureau's Young and Young Technological and Innovative Talent Support Project
.
The phenotypic characteristics and induction mechanism of CD4+ Tregs induced by super antigen Source: Shenyang Institute of Applied Ecology, Chinese Academy of Sciences
