Sun Yat-sen University has made a major breakthrough in the research of breast cancer treatment

reporter from Zhongshan University was informed that Sun Yat-sen University affiliated with the secondHospitalProfessor Song Erwei in breast cancer treatment made a major breakthrough, the results of the research has been scheduled to2
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2007 in the international biology industry authoritative journal CellThe research group first proposed that low-dose chemotherapy pressure can enrich breast cancer stem cells, which laid a good model for the study of breast cancer stem cells, and used chip technology and various molecular biology techniques to clarify the molecular regulation mechanism of breast cancertumorstem cells "dryness", lay the foundation for its molecular target treatment, and is an important breakthrough in the basic theory oftumorAccording to Song, the latest research found why cancer is difficult to cure, the key is in a small number of malignant tumor cells "cancer stem cells", although the proportion is not large, but the capacity of tumor is particularly strong, is considered to be a malignant tumor tumor,development,metastasis and the root cause of recurrence after treatmentThe research, which he led, was successful in interfering with "cancer stem cells" that inhibitbreasted breast cancer using RNA gene interference techniquesBy experimenting in mice, he found that a small molecule RNA called "let-7" had a low expression in breast "cancer stem cells", and through viral vectors, synthetic proteins were accurately imported into "cancer stem cells" to restore the expression of "let-7" and found that "let-7" was found to be "Stem cell characteristics"
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these characteristics are cancer stem cells to produce tumor , lead to cancer cell metastasis and produce resistance to treatment) were significantly inhibited, "cancer stem cells" in vitro and body self-proliferation ability , multi-directional differentiation and tumor capacity are significantly reduced Therefore, small molecule RNA interference can be an effective treatment for breast cancer stem cells Although the theory of tumor stem cells is still controversial, the project of Songer Wei Group, derived from in vitro research on clinical chemotherapy patient specimens, to further in-depth research on the mechanism and function of the animal, can not only provide a good model from basic research, chemotherapy-rich T-IC results are also of general significance to other tumor stakes; The results of the results of expression differences help to understand
the precise mechanism sequester of resistance to tumor , differentiation, proliferation, invasion, metastasis, apoptosis and radiotherapy chemotherapy, help to involve the research and development of targeted drugs represented by let-7, and the expression level of let-7 in breast cancer tumors is of great clinical significance in judging prognosis and sensitivity to chemotherapy At present, , the incidence of breast cancer in China's major cities as high as 5 per million, and at a rate of 3% per year to increase , and found in the late middle and late stage, like other cancers, the main means of treating breast cancer at this stage or chemotherapy and radiotherapy, or the breast part of the lesions all surgery are not cure, and generally only in the early detection stage of breast cancer can produce a certain effect Song is a "sea return" scholar at Harvard University and is known for his scientific research on RNA gene interference 2
003, he successfully applied RNA gene interference technology to the model of protecting explosive hepatitis in mice for the first time, laying the foundation for the application of this technology to the of diseases in humans, ranking fourth in the "
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003 World's Top 10 Technology Breakthroughs" in the American journal Science