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Picture: Croft Lab captured how skin cell proliferation is reduced when TWEAK activity is blocked, as seen in psoriasis (purple staining)
Approximately 7.
Dr.
Now, Croft and his team at LJI's Autoimmune and Inflammation Center have discovered how a key protein called TWEAK destroys the skin cells of patients with psoriasis
"We think TWEAK may be considered a potential target for the treatment of psoriasis," said Dr.
These findings build on the previous work of Croft Labs, which shows that TWEAK can interact with the most common skin cell-keratinocytes
This new study shows that TWEAK does not work alone
"The fact that they work together shows that this disease is essentially driven by these three specific proteins at the same time," Croft said
To test this, the researchers used a mouse model of psoriasis to compare the effects of tweak inhibitors with therapies that inhibit IL-17 or TNF
The research results show that the team's research direction is correct
Croft believes that although human clinical trials are still to be completed, fine-tuned inhibitors still have broad prospects in the treatment of a variety of skin diseases
His laboratory is currently studying the role of TWEAK in atopic dermatitis (also known as eczema), which is a very common skin inflammation, especially in infants and young children
He said: "Of course there is still much room for improvement in the treatment of patients with atopic dermatitis
Article title
TWEAK functions with TNF and IL-17 on keratinocytes and is a potential target for psoriasis therapy
