Successful medium-term somatic cloning of cattle by Sino French cooperation

Introduction: Zhou Qi, a biologist of the Chinese Academy of Sciences, cooperates with scientists of the National Institute of agronomy of France to develop the world's first medium-term somatic cloned cow by improving the cell cycle synchronization method and using "injury resection" Now the cloned cow has been born for nearly three months, healthy and lively, and all physical and chemical indicators are normal The calf was born at the time of China's successful bid for the Olympic Games To congratulate and pay tribute to the Chinese scientists who participated in the research, the French National Institute of Agronomy decided to name the calf "Olympic 2008" According to scientists, before the birth of the Olympic Games in 2008, the world's somatic cloned cattle were produced with dormant cells or growing cells The cell cycle of these cells is not the same as that of the egg cells after the nuclear transfer to the enucleated egg cells However, the synchronization and coordination of cell cycle can improve the efficiency of animal cloning, and it is also an important means to study the relationship between cell nucleus and cytoplasm Therefore, some laboratories in the world engaged in the research of cloned cattle have been trying to clone cattle with metaphase somatic cells for a long time, but none of them has been successful Scientists in Germany and the Czech Republic even think that using metaphase somatic cells in the research of cloned cattle will cause chromosomal abnormalities of cloned embryos Can we artificially adjust the cell cycle of bovine somatic cell nucleus to the same mitotic metaphase as the egg cell, and use the metaphase somatic cell nucleus as the donor to produce cloned cattle? In order to solve this problem, Chinese and French scientists have carried out in-depth research on cell cycle They have carried out long-term research on early gene expression and factors affecting the development of cloned embryos On this basis, they have improved the method of cell cycle synchronization, and combined with the "injury resection" invented by Chinese biologist Zhou Qi, the result is that the world's first medium-term somatic cloned cow is bred The researchers said that this technology will greatly improve the efficiency of animal cloning, which is of great significance to promote the research of cloning technology (author:) share to feed Weibo share to: