Successful lysing of the oxpox virus can be used to make COVID-19 vaccine!

May 22, 2020 /
BiovalleyBIOON /-- A vaccine first introduced in the late 18th century could help today's researchers find a way to fight coronavirusesDrAmy MacNeill, a veterinary pathologist at Colorado State University (CSU), and her team are using the bovine pox virus -- the first vaccine for smallpox -- to create a vaccine that prevents coronavirusMacNeill's lab is dedicated to genetically modifying large DNA viruses, mainly pox viruses, to create cancer therapiesPox viruses are particularly easy to modify because they require relatively little operation to achieve stable protein expression"I've been using these viruses for a long time to develop cancer treatments, so developing a vaccine to prevent coronaviruses seems like a logical step," saidMacNeillimage source: https://cn.bing.com
proteins on pathogensviruses enter the body, our immune system discovers the intruder's protein and removes the pathogen through antibody responsesAlthough MacNeill usually uses the pox virus to express, or produces a protein that killstumorcells, she is now trying to modify the protoprotein of the VIRUS's expression OF THE SARS-CoV-2 virusalthough there are dozens of pox viruses present, bovine pox is an easily detoxified or weakened virus, making it safe for humans and ideal for making vaccinesBy modifying its DNA, MacNeill plans to turn bovine pox into acarrier that carries coronavirus protrusion proteins into the body during vaccination Although the protrusion protein alone does not cause infection, the immune system recognizes the protein as a coronavirus and produces antibodies to repel it in preparation for the body's future encounter with the entire virus MacNeill did not create a vaccine that contains all the pathogens, but instead developed a "subunit vaccine" that uses only a fraction of the virus protein to stimulate the immune response The pox virus is the only virus that produces a lot of protein, which triggers a stronger immune response "Compared to other types of vaccines, it does make the immune system excited about problems, and it's safer and more powerful," said MacNeill, a "
two pox viruses are better than one
in addition to using bovine pox as the basis for the vaccine, MacNeill is also exploring the use of mucus omavirus, another type of pox virus that causes rabbit infection, but does not infect humans Like bovine pox, mucus tumors are a pox virus that is easy to control, but it may trigger a lower level of immune response in humans This is a promising alternative for those who are immune suppressed and are unable to produce the antibodies needed to react to a mature vaccine MacNeill has successfully used similar pox viruses to create low-risk treatments for cancer patients and hopes to do the same for people who seem more susceptible to the coronavirus startwithe with mucus, MacNeill and her assistant Laura Ashton are working to recombine the initial stages of the virus production, which is the basis for the actual vaccine The process is fairly simple for researchers -- they've done this with different viruses before -- but they have to consider the mutation "This method is copyandand and paste, but sometimes proteins don't clone correctly," Ashton said We want to be able to insert them easily so we can get ready for the test "
if the candidate mucus tumors created are successful, they will follow the same process as bovine pox Both viruses will then go into testing, in collaboration with CSU colleagues who are exposed to live coronaviruses image source: https://cn.bing.com
multi-strength in a spirit of collaboration, MacNeill's vaccine can be combined with another vaccine to enhance the immune response Although her method is to vaccinate the protrusion protein of the coronavirus into the virus, Dr Gregg Dean is developing a vaccine based on the of bacteria Some vaccines require a booster or multiple injections to be fully effective, and a combination of the two approaches may lead to a more effective and comprehensive immune response "We may be able to trigger a strong systemic response from the virus vaccine and increase respiratory protection from bacteria vaccines," said MacNeill, If we can amplify the immune response in both ways, they will hopefully be able to better protect people "
While many research teams are working on different coronavirus vaccine approaches at the same time, MacNeill believes that these efforts inspire collaboration, not competition "I think it's very important that we try to make all kinds of vaccines and hopefully someone can make them that work well, " says MacNeill, I'm glad there's a possibility of cooperation -- if there's anything I can do to help, there's no doubt I'll help (biovalleybioon.com) References: Poxviruses can yield protein pathways for corona vaccinevirus