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Subcutaneous RNAi therapy ALN-AGT Phase 1 clinical trial results are positive

 Last Update: 2021-04-18
 Source: Internet
 Author: User

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About 1.

ALN-AGT is an RNAi therapy targeting mRNA that expresses angiotensinogen.

In this randomized, double-blind, placebo-controlled clinical trial, a total of 84 hypertensive patients received different doses of ALN-AGT.

Moreover, as the AGT level drops, the patient's blood pressure also drops at the same time.

Note: The original text has been deleted

Reference materials:

[1] Alnylam Presents Positive Late-Breaking Data from Ongoing Phase 1 Study of ALN-AGT, an Investigational RNAi Therapeutic for the Treatment of Hypertension.

[2] Safety, Pharmacodynamics, and Blood Pressure Effects of ALN-AGT, an RNA Interference Therapeutic Targeting Angiotensinogen, in a Randomized Single Ascending Dose Study of Hypertensive Adults.

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