Study on the protective effect of Schisandra on liver

Schisandra chinensis is the mature fruit of Schizandra chinensis (Turcz.) Baill And Schizandra sphenanthera Rehd Et Wils Of Magnoliaceae It is sour, sweet and warm in nature It can regulate lung, heart and kidney meridians It has the functions of benefiting qi, promoting body fluid, nourishing kidney and heart, and astringent and astringent Schisandrin mainly contains schisandrin (schisandrin a), deoxyschisandrin (schisandrin a), r-schisandrin (schisandrin B) and schisandrin Schisandrin is one of the main components, containing more than 20% of the volatile oil, and citral is the main component in the oil It also contains malic acid, tartaric acid, vitamin A, vitamin C, resin, tannin, sugar and arginine The seed still contains about 34% fat oil, and its ash contains iron, manganese, silicon, phosphorus and other minerals Reducing enzyme and protecting liver function: the experiment proved that Schisandra chinensis can inhibit the increase of serum glutamic pyruvic transaminase (CPT) caused by carbon tetrachloride The alcohol extract of seed kernel can obviously reduce the high serum transaminase caused by experimental liver damage But the decoction of pulp or kernel is invalid The results showed that the effective component of enzyme reducing could be dissolved by alcohol, but not in water Some experiments show that r-schisandrin can protect liver cells and accelerate liver regeneration Liver injury was caused by carbon tetrachloride After treatment with Schisandra preparation, the necrosis area of liver lobule was reduced, the hepatocytes containing fatty oil were significantly reduced, hydrolase, oxidase and dehydrogenase were significantly recovered Compared with the control group, there were more mitochondria in the central necrosis area of liver cells in the treatment group, and further observed the nucleic acid and general protein in the hepatocytes of animals treated with Schisandra preparation The content of disulfide group of qualitative, basic protein and binding thioamino group was higher than that of the control group Therefore, Schisandra chinensis is helpful to the synthesis of protein in hepatocytes, so that mitochondria can be restored and increased, corresponding enzyme activity can be increased, hepatocytes can be restored and regenerated, and play the role of reducing enzyme and protecting liver It is suggested that Schisandra oil emulsion can increase the content of AMP in plasma and liver tissue of mice, and whether the protective effect of Schisandra oil emulsion can affect cell metabolism by increasing camp is worthy of further study In vivo process: after intravenous injection of 3H schisandrin a to mice, the half-life of drug distribution phase was 7.98min, and the elimination phase T1 / 2 was 18.14h, indicating that the distribution in blood was rapid and the elimination phase was slow, and reached the peak 14.1h after gavage The bioavailability within 72h was only 45.36%, indicating poor absorption in gastrointestinal tract This product is mainly distributed in liver, gall bladder and spleen, and forms a large number of lipid soluble metabolites in liver (68.5%) The total excretion of feces and urine was 79.01% in 72h, which indicated that the excretion of the product was slow, which was beneficial to the efficacy The metabolism and brain distribution of schisandrin a in rats were determined by thin-layer UV scanning The results showed that the drug absorbed rapidly and completely from gastrointestinal tract, distributed widely, most in lung, most in thalamus, striatum and hippocampus in brain, and metabolized and excreted rapidly Clinical application: in the treatment of jaundice free hepatitis and chronic persistent hepatitis, Schisandra chinensis was used as the end of the study, taking 3G every time, three times a day, for a period of one month, and the effect of reducing glutamic pyruvic transaminase was obvious During the period of taking medicine, when transaminase drops to a certain level, it will no longer drop, or the treatment effect is not obvious, it can be added to the daily dosage of 12-18g With Schisandra pill, it also has better curative effect It is reported that for acute bacillary dysentery and other acute intestinal infection, it has good curative effect to take Schisandra 2G, or 90% tincture or extract 0.5g, three times a day For chronic enteritis, bacillary dysentery, dyspepsia and diarrhea, it can be combined with Psoralea, Evodia rutaecarpa, nutmeg, etc to improve the resistance, anti infection, aid digestion and stop diarrhea The usual dosage is 3-9g.