 Home > Biochemistry News > Biotechnology News > Study finds inhibition of PDK1 holds promise for acute myeloid leukemia

Study finds inhibition of PDK1 holds promise for acute myeloid leukemia

 Last Update: 2022-04-16
 Source: Internet
 Author: User

Tags

fuel journal

1 3 dichlorobenzene

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

Acute myeloid leukemia (AML) remains difficult to treat because of high genetic heterogeneity not only between different patients, but also between subclonal populations of cancer cells within the same patient

Now, in a new study, researchers from research institutions such as the University of Groningen in the Netherlands and the University of Barcelona in Spain have found that a key enzyme in glucose metabolism, pyruvate dehydrogenase kinase 1 (PDK1), is a key enzyme in leukemia stem cells containing a large number of leukemia stem cells.

PDK1: a determinant of different metabolic states

In the new study, PDK1 was identified as a determinant of different metabolic states

Integrated metabolomic, proteomic and transcriptomic analysis of major energy flows in AML and normal hematopoietic stem/progenitor cells

Image via Nature Communications, 2022, doi:10.

The authors applied metabolomic, proteomic, genomic and transcriptomic techniques, as well as gene ontology and gene set enrichment analysis (GSEA), among others

These findings also indicate that inhibition of PDK1 induces mitochondrial stress and improves the efficacy of glutaminase inhibitor-based antitumor therapies

Note: The original text has been deleted

References:

Ayşegül Erdem et al.

This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

Related Products

L-Ascorbate-2-Monophosphate Feed Grade

CAS No.: 109620-90-8

Feed Grade

Potassium Sorbate from reliable manufacturer

CAS No.: 590-00-1

Food Grade

Doxycycline Hydrochloride

CAS No.: 10592-13-9

Pharmaceutical Grade

Hot Tags

united states jobs(223)

jobs united states(236)

1 year treasury(277)

1 year subscription(296)

single use technology(195)

announcements today(81)

ups united states(221)

united states logo(227)

80 20 company(94)

healthy food name(42)

Hot Articles

The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.