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, published in the United States, showed that alcohol can damage the DNA of hematopoietic stem cells in mice. The study may help explain the well-known link between alcohol consumption and an increased risk of cancer.
alcohol consumption is a public health issue and a factor in diseases and global mortality. Ketan Patel and colleagues at the Molecular Biology Laboratory at the Cambridge Medical Research Council in the UK have shown that acetaldehyde, an alcohol metabolite that is naturally produced at low concentrations of alcohol, causes double-stranded fractures of blood stem cell DNA in mice. Although some DNA fractures were subsequently repaired, residual damage was widespread, including the removal of certain areas and the staining of the weight row. These genetic changes are then passed on to countless offspring of these hematopoietic stem cells, blood cells.
for most people, acetaldehyde is a fleeting by-product of alcohol and is oxidized into acetate by acetaldehyde dehydrogenase 2. However, about 540 million people in Asia carry a mutation in the ALDH2 gene that prevents them from degrading acetaldehyde. Alcohol intake is known to increase the risk of esophageal cancer in these people. The new study suggests they may also be susceptible to alcohol-induced age-related blood diseases, although further research is needed to determine whether these findings can be translated into clinical practice. (Source: Science Network Zhang Zhang)
