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Figured: The study focused on suprateral ePEND memonomas with the multiple gene C11orf95 fused with RELA [ST-RELA] in children
A study conducted by researchers in Brazil, Australia, Austria and the United States made a major discovery of a childhood cancer that has no approved treatment and has a low
Ependymomas are various central nervous system tumors that can basically only be treated with surgical resection and radiation therapy
The study is part of
Ependymoma is the third most common type of childhood brain and spine tumor, most common in infants and young children
Through a range of advanced techniques, the researchers found that the so-called hedgehog signaling pathway (Hh) is highly activated
Treated tumor analysis shows that primary cilia disappear, making them resistant to the drug
The researchers found that the formation of primary cilia is controlled
Since the drug combination worked well on in vitro models, they next collaborated with a research team in Australia to test
The researchers believe that the blood-brain barrier may have prevented the drug from reaching the tumor
choose
Researchers are now looking for other drugs with the same effect that can penetrate the blood-brain barrier, which could lead to the first treatment of the disease
For Elvis Terci Valera, professor of the FMRP-USP Children's Health Program and the last author of the paper, the findings open up prospects
"Another strategy is to apply these more modern drugs directly to the cerebrospinal fluid and spinal cord
